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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

DOI:
10.3791/4060-v

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10:53 min

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November 23, 2012

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, ,
1Department of Translational Imaging,The Methodist Hospital Research Institute, Houston, 2Diabetes Research Center,The Methodist Hospital Research Institute, Houston

Chapters

  • 00:05Title
  • 01:30Animal Preparation and Cold Treatment
  • 02:18Injection of FDG
  • 04:01Micro-PET/CT Imaging
  • 07:29Post-imaging Analysis
  • 08:54Results: FDG Uptake in Mouse BAT
  • 10:06Conclusion

Summary

Automatic Translation

Automatic Translation

A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.

Tags

Functional ImagingBrown FatMice18F-FDG Micro-PET/CTEnergy ExpenditureThermogenesisSympathetic Nervous SystemAdrenergic ReceptorBody Mass Index (BMI)Diabetic ParametersAnti-obesity/anti-diabetes TherapyEnergy BalanceCold Challenge-based Positron Emission Tomography (PET)Standardized ProtocolSmall Animal ModelsC57BL/6J MiceFasting Conditions18F-Fluorodeoxyglucose (FDG)Micro-PET/CT SystemPET ImagesCT Images

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