Therapeutic Ultrasound
Therapeutic Ultrasound - Related Videos
05:04
An Ultrasound-Guided Injection of Therapeutic Drugs into Human Salivary Glands
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2025
The video demonstrates an ultrasound-guided injection technique for administering therapeutic drugs into the salivary glands of a human patient.
05:05
Ultrasound Cyclo Plasty in Eyes with Glaucoma
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Cited by 17 •
2018
Glaucoma is a chronic disease with progressive degeneration of optic nerve fibers resulting in decreased visual field. Elevated intraocular pressure is considered the most important and the only treatable risk factor. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty, for reducing intraocular pressure in glaucoma patients.
08:24
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
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Cited by 19 •
2011
Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
08:51
Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
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Cited by 13 •
2012
This protocol describes the stimulation of cultured fibroblasts with low-intensity pulsed ultrasound, which drives focal adhesion formation and Rac1 activation by mimicking engagement of the transmembrane matrix receptor, syndecan-4. This approach allows investigation of a successful clinical technique at the cellular level, thereby providing opportunities for refinement of the therapy.
FAQs
The same acoustic energy can act through distinct mechanisms depending on exposure conditions. Focused waves may generate localized mechanical pressure, heating, or both, allowing researchers to influence selected tissue rather than the entire brain. These effects support different goals, including neuromodulation, targeted delivery across the blood-brain barrier, and experimental investigation of neural circuits.
Acoustic frequency, intensity, focal position, and exposure duration all influence the resulting tissue response. Tissue properties also affect how energy travels and concentrates, particularly when the target lies behind the skull. Adjusting these variables changes whether mechanical effects, heating, or a combination predominates, so treatment design must match the intended biological outcome.
Microbubble contrast agents enable acoustic exposure to produce a temporary, targeted opening of the blood-brain barrier. This adds a delivery mechanism to the physical effects produced by the sound field, potentially directing therapeutic substances toward selected brain regions. The approach is especially relevant when researchers need localized access rather than broad exposure throughout the nervous system.
Planning requires explicit control of the acoustic frequency, intensity, focal location, and exposure duration, together with consideration of tissue properties. These parameters determine where energy is concentrated and which biological effects are likely to occur. Careful control supports safety and reproducibility, allowing separate experiments or treatments to produce interpretable and comparable outcomes.
In neuroscience, focused acoustic energy can be directed through the skull toward selected structures for noninvasive neuromodulation. Researchers can also combine the technique with microbubble contrast agents for targeted blood-brain barrier opening, or use its effects to investigate brain circuits. These applications connect physical energy delivery with studies of neurological disorders and tissue function.
Its potential outcomes include localized mechanical modulation, noninvasive alteration of neural activity, temporary access across the blood-brain barrier, and targeted support for drug delivery. Researchers may also use these effects to examine brain circuits and neurological disorders. Interpreting results requires relating the observed response to the acoustic settings and tissue characteristics used during exposure.