Drug Reservoirs
Drug Reservoirs - Related Videos
01:30
Reservoir of Infection
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2026
Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
01:10
Veins as Blood Reservoirs
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2024
Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance vessels. When...
10:38
Measurement of the Rheology of Crude Oil in Equilibrium with CO2 at Reservoir Conditions
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Cited by 2 •
2017
A method for measuring the rheology of crude oil in equilibrium with carbon dioxide at reservoir conditions is presented.
08:02
Reservoir Condition Pore-scale Imaging of Multiple Fluid Phases Using X-ray Microtomography
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Cited by 28 •
2015
We present a methodology for the imaging of multiple fluid phases at reservoir conditions by the use of x-ray microtomography. We show some representative results of capillary trapping in a carbonate rock sample.
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Cited by 4 •
2016
Here we describe a protocol using the web-based drug repurposing hypothesis generation tool: "RE:fine Drugs." This protocol can be modified to a user's preferences at the level of the query type (gene, drug or disease) and/or the range of available advanced options.
FAQs
Reversible binding temporarily retains a drug within tissue components rather than allowing all of it to remain freely available in circulation. As the free drug concentration changes, bound drug can dissociate and diffuse back toward the circulation or target site. This exchange creates a delayed release pattern that may sustain pharmacological effects after the initial circulating concentration declines.
Lipid-rich compartments can accumulate drugs that have an affinity for those tissues, creating a concentrated storage site outside the immediately circulating drug pool. The drug may then return gradually to the circulation as it diffuses away from the compartment. This behavior can lengthen exposure and complicate predictions of distribution and clearance compared with drugs that remain mainly in accessible fluid spaces.
A tissue or cellular reservoir develops through reversible association with biological components or accumulation in a particular compartment. A depot formulation, in contrast, is a specialized delivery system designed to retain the drug and release it over time. Both can prolong exposure, but distinguishing their sources helps pharmacologists interpret distribution patterns and evaluate controlled-release treatment strategies.
Stored drug may continue returning to the circulation after new doses are administered, so elimination does not immediately remove the total amount present in the body. With repeated dosing, release from the reservoir can overlap with newly absorbed drug and increase overall accumulation. Consequently, therapeutic or unwanted effects may persist longer than expected when dosing stops or changes.
Pharmacologists account for reservoirs because they alter the relationship between circulating drug levels and the total amount present in the body. Temporary storage can delay apparent clearance, extend drug exposure, and produce effects that outlast initial distribution. Incorporating these behaviors into pharmacokinetic interpretation supports more realistic predictions of duration of action and helps identify potential accumulation.
They are useful when a treatment goal includes sustaining drug availability, prolonging therapeutic effects, or reducing dosing frequency. A depot formulation can provide a planned storage site, while tissue or cellular retention may influence exposure after administration. Researchers must balance prolonged delivery against delayed clearance and extended adverse effects so that the release pattern supports treatment safety.