Intramuscular Injection
Intramuscular Injection - Related Videos
12:28
Preparing and Administering Intramuscular Injections
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2017
Source: Madeline Lassche, MSNEd, RN and Katie Baraki, MSN, RN, College of Nursing, University of Utah, UT Intramuscular (IM) injections deposit medications deep into the muscle tissue. Since muscle fibers are well perfused, this route of administration provides quick uptake of the medication and allows for the administration of relatively large volumes. Skeletal muscles have fewer pain-sensing nerves than subcutaneous tissue, which allows for the less painful administration of irritating drugs...
02:47
Intramuscular (IM) Injection: Compound Delivery into the Dorsal Muscle of an Adult Zebrafish
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2023
This video describes the technique of intramuscular injection for delivering compounds into the dorsal muscles of an adult zebrafish.
03:31
Intramuscular Injections Along the Motor End Plates to Shuttle Tracers Directly into Rat Motor Neurons
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2025
Source: Mohan, R., et al. Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons. J. Vis. Exp. (2015)This video demonstrates the targeted delivery of a fluorescent neuronal tracer into motor neurons via intramuscular injection at the motor end plates (MEPs). It outlines the steps involved in preparing the rat, injecting the tracer, and assessing labeled motor neurons for neurotherapeutic potential.
10:57
Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons
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Cited by 20 •
2015
The efficacy of intramuscular uptake and retrograde transport of molecules to corresponding motor neurons depends on the location of the injection sites with respect to the motor end plates (MEPs). Here, we describe how to locate MEPs on skeletal muscles to optimise retrograde transport of tracers into motor neurons.
09:19
A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle
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Cited by 10 •
2022
The replacement of healthy muscle tissue with intramuscular fat is a prominent feature of human diseases and conditions. This protocol outlines how to visualize, image, and quantify intramuscular fat, allowing the rigorous study of the mechanisms underlying intramuscular fat formation.
FAQs
Muscle perfusion affects how quickly the deposited medication enters the bloodstream. Better perfusion can support more rapid systemic availability, whereas differences in tissue characteristics may alter the rate and consistency of absorption. This variable helps explain why the same dose may not produce identical timing of effects in every injection setting.
Aqueous solutions generally enter circulation more readily, while depot preparations are formulated to remain at the injection site and support a more sustained effect. The formulation therefore influences both absorption rate and duration. Pharmacology uses this distinction to match a medication's delivery pattern with the desired timing of systemic action.
The selected site and the characteristics of the underlying tissue can influence absorption, discomfort, and the likelihood of tissue injury. Site selection should therefore support deposition in muscle while limiting avoidable local problems. These considerations are pharmacologically important because they affect whether a measured dose produces reliable systemic exposure.
Administration requires selecting an appropriate muscle site, preparing a measured dose, penetrating the muscle with a needle, and depositing the medication in the intended tissue. Proper technique supports predictable absorption and helps reduce pain and tissue injury. The procedure must also account for the drug formulation and the tissue characteristics at the selected site.
This route may be selected when oral delivery is unsuitable or when a sustained effect is desired. Its pharmacological applications include vaccination and administration of selected antibiotics, hormones, analgesics, and other medicines. The choice depends on the medication's formulation and the intended pattern of systemic exposure rather than on route preference alone.
Evaluation focuses on whether the dose produces reliable systemic absorption while limiting local pain and tissue injury. The expected timing and duration of effects also depend on muscle perfusion, injection site, tissue characteristics, and formulation. Comparing these factors helps interpret variation in response and supports appropriate use of aqueous or depot preparations.