Neurochemical Changes
Neurochemical Changes - Related Videos
01:26
Neurochemical Transmission: Sites of Drug Action
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2023
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
07:04
Physiological, Morphological and Neurochemical Characterization of Neurons Modulated by Movement
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2011
A technique is described to quantify the in vivo physiological response of mammalian neurons during movement and correlate the physiology of the neuron with neuronal morphology, neurochemical phenotype and synaptic microcircuitry.
08:54
Immunostaining of Biocytin-filled and Processed Sections for Neurochemical Markers
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Cited by 28 •
2016
This protocol presents a method for the morphological recovery of neurons patched during electrophysiological recordings using biocytin filling and subsequent immunohistochemical postprocessing. We show that thick biocytin-filled sections that were stained and coverslipped can be restained with a second primary antibody days or months later.
14:37
Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
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Cited by 39 •
2014
Cortical networks are controlled by a small, but diverse set of inhibitory interneurons. Functional investigation of interneurons therefore requires targeted recording and rigorous identification. Described here is a combined approach involving whole-cell recordings from single or synaptically-coupled pairs of neurons with intracellular labeling, post-hoc morphological and immunocytochemical analysis.
07:34
Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection
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Cited by 20 •
2019
In this study, we modify carbon-fiber microelectrodes with gold nanoparticles to enhance the sensitivity of neurotransmitter detection.
FAQs
Binding is only one point in the signaling sequence. A chemical messenger may be present at a different level, released in a different amount, received through receptors, or broken down at a different rate. These changes can modify electrical signaling and downstream activity, giving researchers several mechanisms to examine when relating neural communication to psychological effects.
Stress, learning, medication, and environmental conditions can each serve as contexts in which neurochemical changes are examined. Comparing these contexts helps researchers ask whether altered chemical signaling accompanies differences in emotion, cognition, motivation, or behavior. This comparison connects changes in neural communication with specific psychological situations rather than treating brain activity as context-free.
Serotonin, dopamine, glutamate, and GABA provide different chemical targets for studying communication between neurons and between the brain and body. The key research question is how their levels, release, reception, or breakdown relate to signaling. Examining these messengers helps researchers connect chemical activity with neural circuits and observed psychological outcomes.
Measurement adds a biological layer to observations of behavior and mental processes. Researchers can examine neurochemical activity alongside emotion, cognition, motivation, or behavior, then evaluate how changes in signaling correspond with those outcomes. This approach does not replace psychological observation; it helps link observable patterns to underlying neural processes.
Medication provides a research context for examining whether changes in neurochemical signaling accompany changes in psychological functioning. Investigators can relate drug-associated alterations to emotion, cognition, motivation, behavior, or other observed outcomes. In this way, neurochemical research contributes to understanding how therapeutic drugs may affect neural communication and why those effects matter psychologically.
They offer a way to connect biological processes with psychological functioning. By studying signaling alongside emotion, cognition, motivation, and behavior, researchers can investigate how brain and body communication relates to mental health conditions. This evidence can also inform research on therapeutic drugs and their effects, helping integrate biological and psychological perspectives.