Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Host cell factors play a critical role in the establishment and maintenance of Kaposi's sarcoma (KS). We outline methods to identify host cell factors altered in KSHV-infected DMVEC cells, and in KS tumor tissue. Cellular genes altered by virus will serve as potential target(s) for novel therapeutics.

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Kaposi's Sarcoma-associated Herpesvirus Dysregulated Genes KSHV HIV/AIDS Malignancy Southern Africa Angioproliferative Tumor Vascular Endothelial Cells B Cell Lymphoproliferative Diseases Pleural Effusion Lymphomas Multicentric Castleman's Disease Lytic Replication Oncogenesis Tumor Progression Host-factor Determinants Prognostic Markers Metastasis Therapeutics Dermal Microvascular Endothelial Cells (DMVEC) Microarray Analysis Protein Expression Immunoblot Dual Labeled Immunofluorescence Transcriptional Expression Quantitative Real-time Polymerase Chain Reaction (qRT-PCR)

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Journal (Immunology and Infection)

Journal (Immunology and Infection)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

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