A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Matthew Moore; Yifan Hu; Sarah Woo; Dylan O'Hearn; Alexandru D. Iordan; Sanda Dolcos; Florin Dolcos

doi:10.3791/50991

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

一个全面协议的内侧颞叶结构的手动分割

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12:30 min

July 2, 2014

DOI: 10.3791/50991-v

Matthew Moore*¹, Yifan Hu*¹, Sarah Woo¹, Dylan O'Hearn¹, Alexandru D. Iordan^2,3, Sanda Dolcos¹, Florin Dolcos^1,2,3

¹Psychology Department,University of Illinois Urbana-Champaign, ²Neuroscience Program,University of Illinois Urbana-Champaign, ³Beckman Institute for Advanced Science and Technology,University of Illinois Urbana-Champaign

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本研究为手动追踪内侧颞叶（MTL）结构提供了一套全面的指南。该协议可应用于涉及健康和临床组 MTL 的结构和/或组合结构功能磁共振成像（MRI）研究的研究。

该程序的总体目标是说明如何在高分辨率磁共振图像上手动追踪人体内侧颞叶结构。这是通过首先识别大脑中的杏仁核并从前缘到后缘系统地追踪它来实现的。第二步是定位海马体的纵向范围和一般边界，然后沿前后方向逐片追踪。

接下来，追踪海马旁回的前部结构，即平行的海马间和会阴皮层，以更好地适应它们相互边界的变化。最后一步是追踪海马旁回的后段，即海马旁皮层以相同的前后方式。最终，这种手动追踪程序可用于获得所有内侧颞叶结构的 3D 渲染和体积统计数据。

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神经科学第89期解剖分割内侧颞叶 MRI检查手动跟踪杏仁核海马边缘皮层内嗅皮质海马旁皮质