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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Article DOI: 10.3791/51729-v • 08:14 min • July 31st, 2014
July 31st, 2014 •
*1,2, *1,2, 1,2, 3,4, 1,2
1Institute for Stroke and Dementia Research, University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology, University Heidelberg, 4Imperial College, Charing Cross Hospital
* These authors contributed equally

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总结概括
Automatic Translation

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

Tags

Modeling Stroke Mice Permanent Coagulation Distal Middle Cerebral Artery Therapeutical Options Novel Therapeutic Strategies Sub-acute Phase Chronic Phase Stroke Inflammation Angiogenesis Neuronal Plasticity Regeneration Experimental Stroke Models Clinical Relevance Low Mortality High Reproducibility Transcranial Coagulation Model Infarct Volume
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