对于耐药性突变对激酶抑制剂的筛选和验证方法
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December 07, 2014
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针对激酶抑制剂治疗遗传性的出现带来了有效的癌症治疗显著的挑战。对新开发的药物鉴定和耐药突变特性有助于更好的临床管理和下一代药物设计。在这里，我们描述了体外筛选及耐药突变的验证协议。
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Cite this Article
Kesarwani, M., Huber, E., Kincaid, Z., Azam, M. A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors. J. Vis. Exp. (94), e51984, doi:10.3791/51984 (2014).
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