A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Kasper J. Kyng; Torjus Skajaa; Sigrid Kerrn-Jespersen; Christer S. Andreassen; Kristine Bennedsgaard; Tine B. Henriksen

doi:10.3791/52454

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Medicine
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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

新生儿缺氧缺血性脑病的小猪模型

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10:30 min

May 16, 2015

DOI: 10.3791/52454-v

Kasper J. Kyng¹, Torjus Skajaa¹, Sigrid Kerrn-Jespersen¹, Christer S. Andreassen², Kristine Bennedsgaard¹, Tine B. Henriksen¹

¹The Perinatal Research Unit, Department of Pediatrics,Institute of Clinical Medicine, Aarhus University Hospital, ²Department of Otorhinolaryngology and Head & Neck Surgery,Institute of Clinical Medicine, Aarhus University Hospital

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围生期窒息后缺氧缺血性脑病可以使用动物模型进行研究。我们演示了建立新生儿缺氧缺血性脑病仔猪模型所需的程序。

以下实验的总体目标是展示围产期缺氧缺血性脑病的仔猪模型。然后，该模型可用于新生儿脑损伤的调查。首先，在与新生儿重症监护病房相当的环境中对仔猪进行镇静、通气和监测。

本手稿中描述的技术使用振幅积分脑电图来滴定缺氧。根据每项单独研究的弹性，以受控方式诱导动物缺氧，保持振幅积分，抑制脑电图，同时确保生存。在这个为期四天的生存模型中，动物在缺氧后 72 小时被安乐死。

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医药第99 仔猪猪新生儿缺氧缺血性脑病（HIE）窒息缺氧振幅整合脑电图（aEEG的）神经科学脑损伤