Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Surya T. Madabattula; Joel C. Strautman; Andrew M. Bysice; Julia A. O&#8217;Sullivan; Alaura Androschuk; Cory Rosenfelt; Kacy Doucet; Guy Rouleau; Francois Bolduc

doi:10.3791/52741

Journal

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神经科学

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攀登缺陷的神经退行性疾病的果蝇模型定量分析

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

JoVE 杂志
神经科学

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JoVE 杂志神经科学

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

攀登缺陷的神经退行性疾病的果蝇模型定量分析

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18,532 Views

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06:30 min

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June 13, 2015

DOI:

10.3791/52741-v

DOI:

10.3791/52741-v

•

06:30 min

June 13, 2015

•

17 Views

Surya T. Madabattula¹, Joel C. Strautman¹, Andrew M. Bysice¹, Julia A. O’Sullivan¹, Alaura Androschuk¹, Cory Rosenfelt¹, Kacy Doucet¹, Guy Rouleau², Francois Bolduc¹

¹Department of Pediatrics,University of Alberta, ²Montreal Neurological Institute and Hospital,McGill University

Summary

We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.