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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Article DOI: 10.3791/53191-v • 07:21 min • September 28th, 2015
September 28th, 2015 •
1, 1, 1, 1, 1, 2, 1
1Saha Cardiovascular Research Center, University of Kentucky, 2Department of Pharmacology and Nutritional Sciences, University of Kentucky

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Subcutaneous implantation of osmotic pumps provides a convenient approach for prolonged and consistent delivery of compounds. This approach has been used extensively to study both abdominal and thoracic aortic aneurysms in mice.

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Subcutaneous Angiotensin II Infusion Osmotic Pumps Aortic Aneurysms Mice Protocol Calculation Of AngII Amount Dissolution Osmotic Pump Filling Pump Implantation Harvest Of Aortas Visualization Of Aortic Aneurysms Abdominal Aortic Aneurysms Thoracic Aortic Aneurysms Male Hypercholesterolemic Mouse Models Apolipoprotein E Deficient Mice Low-density Lipoprotein Receptor Deficient Mice Female Hypercholesterolemic Mice Normocholesterolemic Mice Human Aortic Aneurysms
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