Waiting
登录处理中...

Trial ends in Request Full Access Tell Your Colleague About Jove
JoVE Journal
Bioengineering

需要订阅 JoVE 才能查看此 内容. 登录或开始免费试用。

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
 

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Article DOI: 10.3791/53885-v 13:34 min April 6th, 2016
April 6th, 2016

章节

总结概括

We present a three-dimensional (3D) lung cancer model based on a biological collagen scaffold to study sensitivity towards non-small-cell-lung-cancer-(NSCLC)-targeted therapies. We demonstrate different read-out techniques to determine the proliferation index, apoptosis and epithelial-mesenchymal transition (EMT) status. Collected data are integrated into an in silico model for prediction of drug sensitivity.

Tags

Keywords: 3D Tissue Engineering In Vitro In Silico Lung Tumor Model Drug Effectiveness Mutational Backgrounds Non-small Cell Lung Cancer Targeted Therapies Cell-specific Responses Pre-clinical Drug Testing Tumor Entities Drug Response Predictions Bioreactor Gefitinib ELISA Ki67 Staining
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter