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免疫与感染

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IL-8瞬时转化的小鼠模型<em>体内</em>长期监测炎症反应

An IL-8 Transiently Transgenized Mouse Model for the <em>In Vivo</em> Long-term Monitoring of Inflammatory Responses

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JoVE 杂志免疫与感染

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

IL-8瞬时转化的小鼠模型<em>体内</em>长期监测炎症反应

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7,401 Views

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08:16 min

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July 07, 2017

DOI:

10.3791/55499-v

DOI:

10.3791/55499-v

•

08:16 min

July 07, 2017

•

7358 Views

Gabriella Bergamini*¹, Fabio Stellari*², Angela Sandri*³, Maria M. Lleo³, Gaetano Donofrio⁴, Francesca Ruscitti^5,2, Federico Boschi⁶, Andrea Sbarbati⁷, Gino Villetti², Paola Melotti⁸, Claudio Sorio¹

¹Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory “D. Lissandrini”,University of Verona ²Corporate Preclinical R&D,Chiesi Farmaceutici S.p.A.³Department of Diagnostic and Public Health, Microbiology Division,University of Verona ⁴Dipartimento di Scienze Medico-Veterinarie,University of Parma ⁵Department of Biomedical Biotechnological and Translational Sciences,University of Parma ⁶Department of Computer Science,University of Verona ⁷Department of Neurological, Biomedical and Movement Sciences,University of Verona ⁸Cystic Fibrosis Regional Center (CFC),AOUI Verona

Summary

这里描述的方法允许通过非侵入性生物发光成像（BLI）在小鼠肺中IL-8启动子依赖性炎症激活的可视化。荧光素酶报告基因构建体的交付时间可以将相同的动物多次进行BLI多至两个月。

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