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Journal / Cancer Research / Ett tredimensionellt thymic kultur system för att …
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Cancer Research

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JoVE Journal Cancer Research
Ett tredimensionellt thymic kultur system för att generera murin inducerad pluripotenta stamcells härledda tumör antigen-specifika thymic emigranter
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Ett tredimensionellt thymic kultur system för att generera murin inducerad pluripotenta stamcells härledda tumör antigen-specifika thymic emigranter

Article DOI: 10.3791/58672-v • 10:44 min • August 9th, 2019
August 9th, 2019 •
*1,2, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1, 3, 1,2
1Surgery Branch, National Cancer Institute, NIH, 2Center for Cell-Based Therapy, National Cancer Institute, NIH, 3Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
* These authors contributed equally

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Denna artikel beskriver en ny metod för att generera tumörantigen-specifika inducerad pluripotenta stamcells-härledda thymic emigranter (iTE) av en tredimensionell (3D) thymic kultur system. iTE är en homogen delmängd av T-celler nära besläktade med naiva T-celler med kapacitet för spridning, minnesbildning, och tumör dämpning.

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Cancer forskning stamceller inducerad pluripotenta stamceller immunologi adoptiv cell överföring T celldifferentiering tumörantigen specificitet 3D-kultur fetal thymic orgel kultur
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