Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Fuliang Luo; Xin Wang; Xiaokang Luo; Bo Li; Desheng Zhu; Hansong Sun; Yue Tang

doi:10.3791/60090

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Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

小鼠右心室系统及缺氧诱发肺动脉高血压的侵入性血液动力学评估

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04:54 min

October 24, 2019

DOI: 10.3791/60090-v

Fuliang Luo¹, Xin Wang¹, Xiaokang Luo¹, Bo Li¹, Desheng Zhu², Hansong Sun³, Yue Tang¹

¹Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College, ²Laboratory Animal Center,Peking University, ³Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College

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在这里，我们提出一个协议，使用开胸手术方法对小鼠的右心室和肺动脉进行侵入性血液动力学评估。

该协议是基于运动动力学评估的开放胸部手术，对小鼠等小动物的右心室和肺动脉压力评估非常有用。此过程的优点是它可以同时生成 VP 和 PAP 参数。因此，对于PAH模型的评价更可取。

首先设置手术设备。在血流动力学实验前，在室温下将压力传感器导管浸泡在0.9%盐水中至少30分钟。然后，将导管连接到压力体积系统。

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医学问题 152 肺高血压血动力学右心室压力肺动脉压力小鼠导管插入缺氧