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Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Article DOI: 10.3791/60090-v • 04:54 min • October 24th, 2019
October 24th, 2019 •
1, 1, 1, 1, 2, 3, 1
1Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Laboratory Animal Center, Peking University, 3Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

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Here, we present a protocol to perform an invasive hemodynamic assessment of the right ventricle and pulmonary artery in mice using an open-chest surgery approach.

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Invasive Hemodynamic Assessment Right Ventricular System Pulmonary Arterial Hypertension Mice Open Chest Surgery Pressure Evaluation Small Animals VP Parameters PAP Parameters PAH Models Pressure Transducer Catheter Saline Solution Calibration Knob Data Acquisition Software Balance Valve Stereo Microscope Small Animal Surgical Table Microsurgery Anesthesia Chest And Neck Fur Removal Supine Position Midline Incision Trachea Exposure Intubation
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