A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

William  K.S. Ojemann; Devon  J. Griggs; Zachary Ip; Olivya Caballero; Hesamoddin Jahanian; Susana Martinez-Conde; Stephen Macknik; Azadeh Yazdan-Shahmorad

doi:10.3791/61098

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates

非人类灵长类动物神经外科规划基于MRI的工具箱

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08:41 min

July 17, 2020

DOI: 10.3791/61098-v

William K.S. Ojemann^1,2, Devon J. Griggs^2,3, Zachary Ip^1,2, Olivya Caballero⁴, Hesamoddin Jahanian⁵, Susana Martinez-Conde⁴, Stephen Macknik⁴, Azadeh Yazdan-Shahmorad^1,2,3

¹Bioengineering Department,University of Washington, ²Washington National Primate Research Center,University of Washington, ³Electrical and Computer Engineering Department,University of Washington, ⁴Department of Ophthalmology,SUNY Downstate Health Sciences University, ⁵Radiology Department,University of Washington

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下面概述的方法旨在提供一个全面的方案，准备非人类灵长类动物（NHP）神经外科使用三维（3D）打印方法和MRI数据提取的新组合。

该协议对神经工程领域意义重大，因为它提供了一个简洁和单模程序，旨在提高非人类灵长类动物神经外科的精度和安全性。这项技术为研究人员提供了独特的能力，可以可视化他们的植入或注射过程的各个方面，并确保他们可以尽可能进入手术室准备。此方法的可视化演示至关重要，因为它突出了生命大小的物理模型对手术规划的影响和清晰度。

要在磁共振成像软件中提取大脑，请打开插件下拉菜单并选择提取大脑。将提取强度阈值设置为 2.5、2.7，将阈值梯度值设置为零。创建大脑图像的位图后，选择图像菜单下的生成曲面，并输入用于创建包含感兴趣区域的位图的阈值。

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