Journal
/
生物学
/
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
JoVE 杂志
生物学
Author Produced
需要订阅 JoVE 才能查看此.  登录或开始免费试用。
JoVE 杂志 生物学
Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

4,245 Views

•

11:15 min

•

July 24, 2021

DOI:

10.3791/62311-v

DOI:
10.3791/62311-v

•

11:15 min
July 24, 2021

•

15 Views
, ,
1Faculty of Medicine and Medical Sciences,University of Balamand, 2Department of Clinical Microbiology,Michigan Health Clinics, 3College of Medicine,Central Michigan University

Summary

Automatically generated

This protocol describes how to study all possible combinations that can be obtained between four drugs in one single experiment. This method is based on the standard 96-well plate micro dilution assay and the calculation of fractional inhibitory concentrations (FICs) to evaluate the results.

Explore More Videos

Quadruple-CheckerboardThree-Dimensional CheckerboardDrug Combination TherapyMicro Dilution TechniqueCombination TestingAntibiotic ResistanceE. Coli ESBL

Read Article

Cite this Article

Isber, C., Stockman, D. L., Daoud, Z. Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations. J. Vis. Exp. (173), e62311, doi:10.3791/62311 (2021).

Download .ris file

Copy

Share Video

.

Copy