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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Article DOI: 10.3791/62932-v • 07:14 min • February 25th, 2022
February 25th, 2022 •
1, 1, 2,3
1Department of Chemical Biology, Tokyo Medical University, 2Division of Molecular and Developmental Biology, National Institute of Genetics, 3Department of Genetics, Graduate University for Advanced Studies (SOKENDAI)

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We describe a protocol to induce phase transition of TAR DNA-binding protein 43 (TDP-43) by light in the spinal motor neurons using zebrafish as a model.

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Optogenetic Phase Transition TDP-43 Spinal Motor Neurons Zebrafish Larvae ALS Cellular Consequence Transparency Visualizing Dynamic Behavior Animal Model Therapy Candidate Intrinsically Disordered Regions Neurotoxicity Optogenetic Expression BAC Transgenesis LED Panel Spectrometer Probe Wavelength Peaking At 456 Nm Optical Sensor
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