A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

Arben Dedja; Claudia Cattapan; Giovanni Di Salvo; Martina Avesani; Jolanda Sabatino; Alvise Guariento; Vladimiro Vida

doi:10.3791/63179

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A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

罗斯手术的啮齿动物模型:全身位置的同源肺动脉移植植入

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11:20 min

April 1, 2022

DOI: 10.3791/63179-v

Arben Dedja*¹, Claudia Cattapan*¹, Giovanni Di Salvo², Martina Avesani², Jolanda Sabatino², Alvise Guariento^1,3, Vladimiro Vida¹

¹Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health,University of Padua, ²Pediatric Cardiology Unit, Departments of Women’s and Children’s Health,University of Padua, ³Labatt Family Heart Centre, Department of Cardiovascular Surgery, The Hospital for Sick Children,University of Toronto

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我们演示了如何建立肺根植入降主动脉的小鼠模型，以模拟Ross手术。该模型能够对全身位置的肺自体移植重塑进行中长期评估，这是制定治疗策略以促进其适应的基础。

先天性主动脉瓣狭窄是先天性心脏病的一个亚组，其特征在于左心室道梗阻，其中病变位于瓣膜水平。可用于矫正先天性主动脉瓣狭窄的选择很多。每个人都有自己的缺点。

儿科人群中一个有趣的治疗选择是将肺亲笔签名转移到名为Ross手术的主动脉位置。在这种情况下，肺动脉瓣被同种移植物取代。肺亲笔签名的特征是生长潜力，并且不具有终身抗凝治疗的风险。

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