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Pooled shRNA Library Screening for at identificere faktorer, der modulerer en lægemiddelresistensfænotype
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Pooled shRNA Library Screening for at identificere faktorer, der modulerer en lægemiddelresistensfænotype

Article DOI: 10.3791/63383-v • 14:51 min • June 17th, 2022
June 17th, 2022 •
1,2, 1,2, 2,3, 2,3, 1,2,3, 1,2,3
1Department of Clinical Haematology, Christian Medical College, 2Department of Biotechnology, Thiruvalluvar University, 3Centre for Stem Cell Research, Christian Medical College

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RNA-interferens (RNAi) screening med høj gennemstrømning ved hjælp af en pulje af lentivirale shRNA'er kan være et værktøj til at detektere terapeutisk relevante syntetiske dødelige mål i maligniteter. Vi tilbyder en poolet shRNA-screeningsmetode til at undersøge de epigenetiske effektorer ved akut myeloid leukæmi (AML).

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Kræftforskning udgave 184 Screening med høj gennemstrømning RNAi-screening shRNA epigenetisk faktor cytarabin AraC-resistens
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