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1Department of Cardiothoracic and Vascular Surgery,German Heart Center Berlin (DHZB), 2Institute of Physiology,Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 3DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 4Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Chapters
- 00:05Introduction
- 00:42Surgical Preparations and Tracheotomy and Mechanical Ventilation
- 02:24Aortic Debanding
- 04:06Tracheal Extubation and Post-Operative Care
- 05:19Results: Analysis of Aortic Blood Flow, Ventricular Function, and Hemodynamics after Debanding Surgery
- 07:09Conclusion
The present protocol describes a surgical procedure to remove ascending-aortic banding in a rat model of pulmonary hypertension due to left heart disease. This technique studies endogenous mechanisms of reverse remodeling in the pulmonary circulation and the right heart, thus informing strategies to reverse pulmonary hypertension and/or right ventricular dysfunction.
