A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Kyoungrae Kim; Erik M. Anderson; Brian J. Fazzone; Kerri A. O&#8217;Malley; Scott A. Berceli; Terence E. Ryan; Salvatore T. Scali

doi:10.3791/63892

JoVE Journal
Medicine

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Medicine

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

血液透析通路相关手功能障碍的小鼠模型

Full Text

2,082 Views

08:39 min

May 31, 2022

DOI: 10.3791/63892-v

Kyoungrae Kim¹, Erik M. Anderson^2,4, Brian J. Fazzone^2,4, Kerri A. O’Malley^2,4, Scott A. Berceli^2,4, Terence E. Ryan^1,3, Salvatore T. Scali^2,4

¹Department of Applied Physiology and Kinesiology,University of Florida, ²Division of Vascular Surgery and Endovascular Therapy,University of Florida, ³Center for Exercise Science,University of Florida, ⁴Malcom Randall Veteran Affairs Medical Center

Please note that some of the translations on this page are AI generated. Click here for the English version.

该协议详细介绍了鼠髂总动脉静脉瘘形成的手术步骤。我们开发了这个模型来研究血液透析通路相关的肢体病理生理学。

这是唯一可用于研究透析通路相关手部缺血机制的动物模型。该模型提供了一个强大的平台来检查尿毒症与动脉静脉瘘手术引起的血流动力学变化引起的神经肌肉扰动之间的复杂相互作用。通路相关的手部功能障碍影响多达60%的血液透析患者，并可能严重影响患者的生活质量。

该模型有助于我们了解残疾并测试新疗法。演示该程序的将是来自我们实验室的博士后研究员Raymond Kim博士。首先，将麻醉小鼠仰卧放在由无菌窗帘覆盖的手术台上，并涂抹眼部润滑剂以保护眼睛在手术过程中不会干燥。

View the full transcript and gain access to thousands of scientific videos

Explore More Videos

医学第183期动静脉瘘手功能障碍血液透析血管外科