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Neuroscience
结合周围神经刺激和可控脉搏参数经颅磁刺激探测感觉运动控制和学习
结合周围神经刺激和可控脉搏参数经颅磁刺激探测感觉运动控制和学习
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Neuroscience
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JoVE Journal Neuroscience
Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

结合周围神经刺激和可控脉搏参数经颅磁刺激探测感觉运动控制和学习

Full Text
3,422 Views
14:47 min
April 21, 2023

DOI: 10.3791/65212-v

Kylee R. Graham*1, Kara D. Hayes*1, Sean K. Meehan1

1Department of Kinesiology and Health Sciences,University of Waterloo

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Please note that some of the translations on this page are AI generated. Click here for the English version.

Summary

短潜伏期传入抑制 (SAI) 是一种经颅磁刺激方案,用于探测感觉运动整合。本文介绍了如何使用SAI来研究感觉运动行为期间运动皮层中的收敛感觉运动环。

Transcript

该技术提供了如何将感官信息整合到运动规划和执行中的见解。可控脉冲参数TMS的实施使我们能够识别特定的运动感觉通路,以及这些通路在神经系统疾病中如何被破坏。运动秤的获取和性能需要在有意识的陈述性和潜意识的程序过程之间取得良好的平衡。

短潜伏期传入抑制是认知如何在健康和临床人群的运动皮层中塑造不同程序性感觉运动回路的潜在标志。传入抑制量化了传入输入对经颅磁刺激引起的运动皮质输出的影响。作为感觉运动统合的衡量标准,它通过探测特定神经元群体对熟练运动行为引起的全球血流动力学和电反应的贡献来补充功能性磁共振成像和脑电图。

传统经颅磁刺激器产生的磁刺激的锁定参数招募了感觉运动回路的混合物。另一方面,可控脉冲参数经颅磁刺激器解锁了几个刺激参数,增强了熟练行为过程中传入抑制探测的感觉运动回路的特异性。评估表演期间的感觉运动抑制对于建立熟练和非熟练运动执行的标志物至关重要。

可靠和有效的标记物是开发增强型运动控制模型的重要一步,该模型将增强或促进健康人群的最佳实践,并通过有效的临床干预最大限度地减少运动障碍的影响。对感觉运动回路和影响其功能的因素的增强建模可以帮助提供功能和功能障碍的客观标志物,从而为健康和神经系统人群的运动表现、技能获取和康复提供最佳实践。继续定义精神运动和药物对运动皮层中会聚的感觉运动回路的影响至关重要。

将传入抑制与脑电图相结合,为量化非运动区域的传入抑制作为运动障碍和神经精神障碍的标志物提供了一个令人兴奋的机会。

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