Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

Olivia N. Reul; Ashtin M. Anneken; Rachel K. Kohler; Dyann M. Segvich; Joseph M. Wallace

doi:10.3791/65616

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Practical Considerations for the Design, Execution, and Interpretation of Studies Involving Whole-Bone Bending Tests of Rodent Bones

设计、执行和解释涉及啮齿动物骨骼全骨弯曲试验的研究的实际考虑因素

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04:20 min

September 1, 2023

DOI: 10.3791/65616-v

Olivia N. Reul¹, Ashtin M. Anneken¹, Rachel K. Kohler¹, Dyann M. Segvich¹, Joseph M. Wallace¹

¹Department of Biomedical Engineering,Indiana University-Purdue University Indianapolis

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Summary

啮齿动物骨骼的机械测试是提取有关骨骼对骨折的易感性信息的宝贵方法。由于缺乏适当的实践理解，结果可能会被过度解释或缺乏有效性。该协议将作为指南，以确保准确执行机械测试以提供有效和功能数据。

Transcript

目前弯曲测试的实验挑战包括:将骨骼一致地放置在相同的方向，记录测试过程中骨骼的断裂过程，以及解释复杂的结果。我们的方案不仅为全骨弯曲测试的测试程序和数据分析提供了指南，还为样品制备和储存提供了指南。这是第一个提出整个协议的实例。

与其他检测方法相比，全骨力学检测是一种快速简便的方法来测量骨折易感性。

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