Naoto Hirano Department of Immunology University of Toronto Biography Publications Institution JoVE Articles Naoto Hirano has not added a biography. If you are Naoto Hirano and would like to personalize this page please email our Author Liaison for assistance. Publications BET Bromodomain Inhibition Enhances T Cell Persistence and Function in Adoptive Immunotherapy Models The Journal of Clinical Investigation. Sep, 2016 | Pubmed ID: 27548527 Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PloS One. 2016 | Pubmed ID: 27213277 CD4(+) and CD8(+) TCRβ Repertoires Possess Different Potentials to Generate Extraordinarily High-avidity T Cells Scientific Reports. Mar, 2016 | Pubmed ID: 27030642 CDR3β Sequence Motifs Regulate Autoreactivity of Human Invariant NKT Cell Receptors Journal of Autoimmunity. Apr, 2016 | Pubmed ID: 26748722 Adoptive T Cell Therapy Targeting CD1 and MR1 Frontiers in Immunology. 2015 | Pubmed ID: 26052329 Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25943533 Specific Roles of Each TCR Hemichain in Generating Functional Chain-centric TCR Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25710913 Human Cell-based Artificial Antigen-presenting Cells for Cancer Immunotherapy Immunological Reviews. Jan, 2014 | Pubmed ID: 24329798 Ex Vivo Expansion of Human CD8 T Cells Using Autologous CD4 T Cell Help PloS One. 2012 | Pubmed ID: 22279573 IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3-Dependent Manner in Human CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22238455 [The Cutting Edge of Antitumor Adoptive Cell Therapy] [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. Oct, 2011 | Pubmed ID: 21971251 Induction of HLA-DP4-restricted Anti-survivin Th1 and Th2 Responses Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21705450 The Third Consensus Conference on the Treatment of Aplastic Anemia International Journal of Hematology. Jun, 2011 | Pubmed ID: 21617886 Establishment of Antitumor Memory in Humans Using in Vitro-educated CD8+ T Cells Science Translational Medicine. Apr, 2011 | Pubmed ID: 21525398 A Panel of Human Cell-based Artificial APC Enables the Expansion of Long-lived Antigen-specific CD4+ T Cells Restricted by Prevalent HLA-DR Alleles International Immunology. Nov, 2010 | Pubmed ID: 21059769 Juvenile Myelomonocytic Leukemia: Epidemiology, Etiopathogenesis, Diagnosis, and Management Considerations Paediatric Drugs. 2010 | Pubmed ID: 20034338 Dissociation of Its Opposing Immunologic Effects is Critical for the Optimization of Antitumor CD8+ T-cell Responses Induced by Interleukin 21 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18829491 Clinical Impact of HLA-DR15, a Minor Population of Paroxysmal Nocturnal Haemoglobinuria-type Cells, and an Aplastic Anaemia-associated Autoantibody in Children with Acquired Aplastic Anaemia British Journal of Haematology. Jul, 2008 | Pubmed ID: 18537977 Long-lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2007 | Pubmed ID: 17363542 Volcanism in Response to Plate Flexure Science (New York, N.Y.). Sep, 2006 | Pubmed ID: 16873612 Identification of an Immunogenic CD8+ T-cell Epitope Derived from Gamma-globin, a Putative Tumor-associated Antigen for Juvenile Myelomonocytic Leukemia Blood. Oct, 2006 | Pubmed ID: 16778141 Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-presenting Cells for the Generation of Effective Antitumor Responses Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16707591 Engagement of CD83 Ligand Induces Prolonged Expansion of CD8+ T Cells and Preferential Enrichment for Antigen Specificity Blood. Feb, 2006 | Pubmed ID: 16239433 The Chemical Structure of the Hawaiian Mantle Plume Nature. Aug, 2005 | Pubmed ID: 16100780 Presence of Anti-kinectin and Anti-PMS1 Antibodies in Japanese Aplastic Anaemia Patients British Journal of Haematology. Jan, 2005 | Pubmed ID: 15638857 Autoantibodies Frequently Detected in Patients with Aplastic Anemia Blood. Dec, 2003 | Pubmed ID: 12947009 The Shared Tumor-associated Antigen Cytochrome P450 1B1 is Recognized by Specific Cytotoxic T Cells Blood. Nov, 2003 | Pubmed ID: 12869499 Human Primary and Memory Cytotoxic T Lymphocyte Responses Are Efficiently Induced by Means of CD40-activated B Cells As Antigen-presenting Cells: Potential for Clinical Application Blood. May, 2002 | Pubmed ID: 11964299 Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunologie und Infektion
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunologie und Infektion