Paula M. Canas Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine University of Coimbra Biography Publications Institution JoVE Articles Paula M. Canas has not added a biography. If you are Paula M. Canas and would like to personalize this page please email our Author Liaison for assistance. Publications Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex Journal of Alzheimer's Disease : JAD. Apr, 2016 | Pubmed ID: 27104908 Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels CNS Neuroscience & Therapeutics. May, 2016 | Pubmed ID: 26843141 Depression As a Glial-Based Synaptic Dysfunction Frontiers in Cellular Neuroscience. 2015 | Pubmed ID: 26834566 Caffeine Acts Through Neuronal Adenosine A2A Receptors to Prevent Mood and Memory Dysfunction Triggered by Chronic Stress Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 26056314 The Role of Parkinson's Disease-associated Receptor GPR37 in the Hippocampus: Functional Interplay with the Adenosinergic System Journal of Neurochemistry. Jul, 2015 | Pubmed ID: 25824528 Adenosine A2b Receptors Control A1 Receptor-mediated Inhibition of Synaptic Transmission in the Mouse Hippocampus The European Journal of Neuroscience. Apr, 2015 | Pubmed ID: 25704806 Hyperactivation of D1 and A2A Receptors Contributes to Cognitive Dysfunction in Huntington's Disease Neurobiology of Disease. Feb, 2015 | Pubmed ID: 25449908 Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety Frontiers in Psychiatry. 2014 | Pubmed ID: 24982640 The P2X7 Receptor Antagonist Brilliant Blue G Attenuates Contralateral Rotations in a Rat Model of Parkinsonism Through a Combined Control of Synaptotoxicity, Neurotoxicity and Gliosis Neuropharmacology. Jun, 2014 | Pubmed ID: 24508709 Predominant Loss of Glutamatergic Terminal Markers in a β-amyloid Peptide Model of Alzheimer's Disease Neuropharmacology. Jan, 2014 | Pubmed ID: 24029236 Adenosine A₂A Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation PloS One. 2013 | Pubmed ID: 24312250 Enhanced Role of Adenosine A(2A) Receptors in the Modulation of LTP in the Rat Hippocampus Upon Ageing The European Journal of Neuroscience. Jul, 2011 | Pubmed ID: 21615561 Adenosine A2A Receptors Control Neuroinflammation and Consequent Hippocampal Neuronal Dysfunction Journal of Neurochemistry. Apr, 2011 | Pubmed ID: 21235574 Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by Beta-amyloid Peptides Via P38 Mitogen-activated Protein Kinase Pathway The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2009 | Pubmed ID: 19940169 Key Modulatory Role of Presynaptic Adenosine A2A Receptors in Cortical Neurotransmission to the Striatal Direct Pathway TheScientificWorldJournal. Nov, 2009 | Pubmed ID: 19936569 Spermine Improves Recognition Memory Deficit in a Rodent Model of Huntington's Disease Neurobiology of Learning and Memory. Nov, 2009 | Pubmed ID: 19632348 GDNF Control of the Glutamatergic Cortico-striatal Pathway Requires Tonic Activation of Adenosine A Receptors Journal of Neurochemistry. Mar, 2009 | Pubmed ID: 19141075 Modification Upon Aging of the Density of Presynaptic Modulation Systems in the Hippocampus Neurobiology of Aging. Nov, 2009 | Pubmed ID: 18304697 A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity As Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-outs The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18354001 Adenosine A2A Receptor Antagonists Exert Motor and Neuroprotective Effects by Distinct Cellular Mechanisms Annals of Neurology. Mar, 2008 | Pubmed ID: 18300283 Adenosine A2A Receptor Blockade Prevents Memory Dysfunction Caused by Beta-amyloid Peptides but Not by Scopolamine or MK-801 Experimental Neurology. Apr, 2008 | Pubmed ID: 18191838 Modification of Adenosine Modulation of Acetylcholine Release in the Hippocampus of Aged Rats Neurobiology of Aging. Oct, 2008 | Pubmed ID: 17481781 Blockade of Adenosine A(2A) Receptors Prevents Staurosporine-induced Apoptosis of Rat Hippocampal Neurons Neurobiology of Disease. Aug, 2007 | Pubmed ID: 17596953 Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization Xavier Morató*1,2, Marc López-Cano*1,2, Paula M. Canas3, Rodrigo A. Cunha3, Francisco Ciruela1,2 1Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 2Institut de Neurociències, Universitat de Barcelona, 3Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra JoVE 55661 Biochemie
Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization Xavier Morató*1,2, Marc López-Cano*1,2, Paula M. Canas3, Rodrigo A. Cunha3, Francisco Ciruela1,2 1Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 2Institut de Neurociències, Universitat de Barcelona, 3Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra JoVE 55661 Biochemie