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JoVE Journal > Behavior
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Summary
Abstract
Introduction
Protocol
Results
Discussion
Disclosures
Acknowledgements
Materials
References
Behavior
Inchworming: A Novel Motor Stereotypie in der BTBR<em> T<sup> +</sup> Itpr3<sup> Tf</sup</em> / J-Maus-Modell von Autismus
Published: July 05, 2014
doi:
10.3791/50791
Please note that all translations are automatically generated.
Click here for the English version.
Jacklyn D. Smith
1
,
Jong M. Rho
1
,
Susan A. Masino
2
,
Richelle Mychasiuk
1
1
Departments of Paediatrics and Clinical Neurosciences, Alberta Children’s Hospital Research Institute
,
University of Calgary Faculty of Medicine
2
Department of Psychology, Neuroscience Program
,
Trinity College
Summary
Abstract
Introduction
Protocol
Representative Results
Discussion
Disclosures
The authors have nothing to disclose.
Acknowledgements
Materials
30 cm X 30 cm Plexiglas box with lid
Can be constructed
IR Camera
Survshop (Calgary, Alberta)
Sony CCD Camera DP955V- 30’ Infrared Armor Dome
Find a camera with high-resolution and zoom capabilities
DVR
Supercircuits (Austin, Texas)
BLACK Enterprise-Class 4-Channel H.264 security DVR with DVD Burner
High data capacity
Sawdust
Same as bedding material
DOWNLOAD MATERIALS LIST
References
McFarlane, H. G., Kusek, G. K., Yan, M., Phoenix, J. L., Bolivar, V. J., Crawley, J. N.
Autism-like behavioral phenotypes in BTBR T+tf/J mice.
Genes, Brain, and Behavior
.
7
, 152-163 (2008).
Crawley, J. N.
Designing mouse behavioral tasks relevant to autistic-like behaviors.
Mental Retardation and Developmental Disabilities Research Reviews
.
10
(4), 248-258 (2004).
Deacon, R.
Digging and marble burying in mice: simple methods for in vivo identification of biological impacts.
Nature Protocols
.
1
(1), 122-124 (2006).
Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., Paylor, R.
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety.
Psychopharmacology
.
204
, 361-373 (2009).
Dudek, B. C., Adams, N., Boice, R., Abbott, M. E.
Genetic influences on digging behaviours in mice (Mus musculus) in laboratory and seminatural settings.
Journal of Comparative Psychology
.
97
(3), 249-259 (1983).
Webster, D., Williams, M. H., Owens, R., Geiger, V., Dewsbury, D. A.
Digging behavior in 12 taxa of muriod rodents.
Animal Learning and Behavior
.
9
(2), 173-177 (1981).
Pobbe, R. H., Pearson, B. L., Defensor, E., Bolivar, V. J., Blanchard, D. C., Blanchard, R. J.
Expression of social behaviours of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system.
Behavioural Brain Research
.
214
, 443-449 (2010).
Lewis, M. H., Tanimura, Y., Lee, L., Bodfish, J.
Animal models of restricted repetitive behavior in autism.
Behavioural Brain Research
.
176
, 66-74 (2007).
Silverman, J. L., Yang, M., Lord, C., Crawley, J. N.
Behavioural phenotyping assays for mouse models of autism.
Nature Reviews
.
11
, 490-502 (2010).
Deacon, R., Rawlins, J.
Hippocampal lesions, species-typical behaviours and anxiety in mice.
Behavioural Brain Research
.
156
, 241-249 (2005).
Pearson, B. L., et al.
Motor and cognitive sterotypies in the BTBR T+tf/J mouse model of autism.
Genes, Brain, and Behavior
.
10
, 228-235 (2011).
Pobbe, R. H., Defensor, E., Pearson, B. L., Bolivar, V. J., Blanchard, D. C., Blanchard, R. J.
General and social anxiety in the BTBR T+ tf/J mouse strain.
Behavioural Brain Research
.
216
(1), 446-451 (2011).
Tags
Inchworming
Motor Stereotypy
BTBR T+ Itpr3tf/J Mouse
Autism Spectrum Disorder
Repetitive Behavior
Juvenile Social Interaction
C56BL/6J Mouse
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Cite This Article
Smith, J. D., Rho, J. M., Masino, S. A., Mychasiuk, R. Inchworming: A Novel Motor Stereotypy in the BTBR
T
+
Itpr3
tf
/J Mouse Model of Autism.
J. Vis. Exp.
(89), e50791, doi:10.3791/50791 (2014).
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