Gold Nanoparticle Array
Gold Nanoparticle Array - Related Videos
08:21
Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
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Cited by 1 •
2017
We demonstrate the fabrication of periodic gold nanocup arrays using colloidal lithographic techniques and discuss the importance of nanoplasmonic films.
13:42
Gold Nanoparticle Synthesis
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Cited by 2 •
2021
A protocol for synthesizing ~12 nm diameter gold nanoparticles (Au nanoparticles) in an organic solvent is presented. The gold nanoparticles are capped with oleylamine ligands to prevent agglomeration. The gold nanoparticles are soluble in organic solvents such as toluene.
07:08
In Situ Synthesis of Gold Nanoparticles without Aggregation in the Interlayer Space of Layered Titanate Transparent Films
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Cited by 1 •
2017
Here, we present a protocol for the in situ synthesis of gold nanoparticles (AuNPs) within the interlayer space of layered titanate films without the aggregation of AuNPs. No spectral change was observed even after 4 months. The synthesized material has expected applications in catalysis, photo-catalysis, and the development of cost-effective plasmonic devices.
12:31
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
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Cited by 17 •
2015
A protocol is provided to select structure-switching aptamers for small molecule targets based on a tunable stringency magnetic bead selection method. Aptamers selected with structure-switching properties are beneficial for assays that require a conformational change to signal the presence of a target, such as the described gold nanoparticle assay.
07:23
An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
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Cited by 5 •
2016
A detailed procedure for the synthesis of a 125I-labeled azide and the radiolabeling of dibenzocyclooctyne (DBCO)-group-conjugated, 13-nm-sized gold nanoparticles using a copper-free click reaction is described.
FAQs
Particle spacing determines how strongly neighboring nanoparticles interact through interparticle coupling. Closely organized particles can produce collective effects that differ from those of isolated particles, changing signal intensity and spectral response. Because the arrangement controls these interactions, adjusting spacing provides a way to tune optical behavior for measurements at biological interfaces and other bioengineering applications.
Localized surface plasmon resonance arises when light drives conduction electrons in the gold nanoparticles to oscillate at characteristic frequencies. This interaction creates an optical response that can be examined through signal intensity and spectral behavior. In an ordered array, particle arrangement modifies that response, allowing the optical properties to be tailored for sensitive biomolecular analysis.
Surface functionalization attaches biomolecules or other biologically relevant components to the array’s surface, improving selectivity in detection. This added molecular recognition helps the platform distinguish particular biomolecular interactions rather than responding only to the gold structure. Functionalization therefore connects nanoscale optical behavior with practical biosensing and analysis at biological interfaces.
Individual gold nanoparticles display localized optical behavior, whereas an ordered array adds collective nanoscale organization. Particle spacing and arrangement can create interparticle coupling, altering the intensity and spectral response compared with isolated particles. This distinction gives arrays an additional design variable, enabling optical properties to be adjusted for detection, imaging, and interaction analysis.
A conceptual workflow begins by establishing the nanoparticle arrangement on a surface or within a structured material, followed by functionalizing the surface with biomolecules when selective recognition is needed. Light is then used to interrogate the array, and changes in signal intensity or spectral response provide optical information for biomolecular detection or interface analysis.
These arrays support sensitive platforms for biomolecular detection, cellular imaging, and analysis of interactions at biological interfaces. Their tunable optical properties also contribute to biosensors and diagnostic technologies, while biomolecular functionalization can improve selectivity. The same platform is relevant to emerging theranostic systems that combine diagnostic and treatment-oriented functions.