Localized Therapeutics
Localized Therapeutics - Related Videos
08:53
In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
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Cited by 1 •
2019
The in vivo immunofluorescence localization (IVIL) method can be used to examine in vivo biodistribution of antibodies and antibody conjugates for oncological purposes in living organisms using a combination of in vivo tumor targeting and ex vivo immunostaining methods.
07:44
Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Cited by 5 •
2016
Salivary gland hypofunction, a major adverse effect of head and neck radiotherapy diminishes a patient's quality of life. The demonstration of efficacy of new therapies in animal models is a prerequisite before clinical transition. This protocol describes retroductal administration and local irradiation of rat submandibular glands.
17:16
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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Cited by 4 •
2010
Bioimaging methods used to assess cell biodistribution of nanoparticles are applicable for therapeutic and diagnostic monitoring of nanoformulated compounds. The methods described herein are sensitive and specific when assessed by histological coregistration. The methodologies provide a translational pathway from rodent to human applications.
01:13
Therapeutic Index
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2025
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
09:01
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
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Cited by 13 •
2013
We describe the method of programming stem cells to overexpress therapeutic factors for angiogenesis using biodegradable polymeric nanoparticles. Processes described include polymer synthesis, transfecting adipose-derived stem cells in vitro, and validating the efficacy of programmed stem cells to promote angiogenesis in a murine hindlimb ischemia model.
FAQs
These mechanisms determine how quickly and where a therapeutic agent becomes available. Degradation can alter the carrier or scaffold over time, diffusion moves the agent through surrounding material, and responsiveness to local conditions can link release to properties at the treatment site. Selecting among these mechanisms helps researchers refine dose and timing rather than treating delivery as instantaneous.
These platforms provide different ways to retain, release, or transport a drug or biologic. Injectable hydrogels can be placed at a selected site, drug-eluting implants can provide a local release source, nanoparticles can transport agents, and engineered scaffolds can combine delivery with tissue-support functions. Platform choice therefore connects the agent’s handling with the needs of the target tissue.
Concentrating activity at a diseased site does not by itself ensure the desired result. The amount delivered, when it becomes available, and how evenly it occupies the target region all influence therapeutic exposure. Bioengineering research therefore treats these variables together with compatibility with host tissue, because an effective design must balance local benefit with safe interaction with surrounding biology.
Design begins by matching the therapeutic agent and intended anatomical site with a suitable vehicle or device. Researchers then consider whether the system should retain, transport, or release the agent, and how degradation, diffusion, or local conditions will shape delivery. The design is refined around dose, timing, spatial distribution, and host-tissue compatibility to support the intended outcome.
Applications described for this approach include cancer therapy, regenerative medicine, infection control, and precision treatment. The same design principle can serve different goals: concentrating therapy at diseased tissue, supporting repair, or limiting exposure beyond the target. This breadth makes localized systems relevant when treatment location matters as much as the identity of the drug or biologic.
Bioengineered hydrogels, implants, nanoparticles, and scaffolds can be designed not only to place a therapeutic agent near a target, but also to support tissue repair. This connection is important in regenerative medicine, where spatially controlled treatment and material compatibility must be considered together. Research consequently examines how delivery design can improve efficacy while accommodating the surrounding host tissue.