Mouse Model Implantation
Mouse Model Implantation - Related Videos
12:39
Implantation of Inferior Vena Cava Interposition Graft in Mouse Model
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Cited by 24 •
2014
To improve our knowledge of cellular and molecular neotissue formation, a murine model of the TEVG was recently developed. The grafts were implanted as infrarenal vena cava interposition grafts in C57BL/6 mice. This model achieves similar results to those achieved in our clinical investigation, but over a far shortened time-course.
03:47
Implantation of a Flexible Biocompatible Probe in a Glioblastoma Mouse Model
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2025
Source: Lefevre, M. C., et al., Flexible Organic Electronic Devices for Pulsed Electric Field Therapy of Glioblastoma. J. Vis. Exp. (2022)This video demonstrates the implantation of a flexible, biocompatible probe in a glioblastoma mouse model to deliver targeted pulsed electric field therapy for neurotherapeutic applications.
02:43
Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model
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2025
This video demonstrates a cell-based tumor vaccination assay. A mouse, intradermally injected with B16-F10 melanoma cells for tumor formation, is vaccinated with B16-F10 cells secreting Flt3L cytokine near the developed tumor. The secreted Flt3L from the vaccine promotes the maturation and proliferation of dendritic cells that then present tumor antigens to T cells in lymph nodes, triggering a targeted anti-tumor immune response.
07:02
Animal Model of Implant-Associated Infections in Mice
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2025
The present protocol describes a mouse model employing subcutaneous dorsal implantation to investigate implant-associated infections, enabling comprehensive investigation of pathophysiological mechanisms and supporting the development of diagnostic criteria with targeted therapeutic strategies.
03:44
A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess
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Cited by 1 •
2025
This protocol describes a unique experimental model of implant-related infections that enables the simultaneous incubation of two implants with bacteria under identical conditions within a single mouse. It also allows precise assessment of biofilm formation on implant surfaces using optimized comparative analytical methods, demonstrating advanced techniques for evaluating biomaterials' antimicrobial properties.
FAQs
The implant is evaluated through the host response at and around the surgical site. Researchers monitor healing and inflammation, then assess whether the material remains compatible with surrounding tissue while supporting the intended function. These observations help distinguish acceptable biological performance from responses that could limit a scaffold, device, cell construct, or therapeutic formulation.
Placement in a defined target tissue links the implant’s performance to the biological environment in which it is intended to function. The site can influence healing, integration, and functional outcomes observed during follow-up. Controlling implantation location therefore helps researchers interpret tissue-specific responses and refine the design of engineered systems.
A living mouse provides an integrated setting in which the implant encounters tissue healing, inflammation, and other host responses over time. This context can expose biological or functional outcomes that are difficult to assess in isolated testing alone. Findings from the model guide optimization before evaluation in larger animal models or clinical settings.
The procedure begins with anesthesia, followed by creation of a defined surgical site and placement of the selected implant in the target tissue. Researchers then close the incision and monitor the animal during healing and later follow-up. This sequence establishes a controlled pathway from implantation to assessment of biological performance and function.
Follow-up commonly focuses on healing, inflammation, integration, and functional outcomes. Together, these measures show how the host responds to the implanted material or construct and whether it performs its intended role. Tracking them over time is important because early surgical responses and later tissue integration may provide different information about system performance.
Researchers use implantation studies to evaluate biocompatibility, tissue regeneration, drug delivery, and device performance in a living organism. The model can compare how engineered systems behave after placement in tissue and can identify design improvements. Its findings support optimization and help determine whether a system is ready for more advanced preclinical or clinical consideration.