Biospec-nano

Biospec-nano refers to the study and use of nanoscale tools, materials, and measurements for examining biological specimens, linking nanotechnology with biological research. In these approaches, samples such as cells, proteins, nucleic acids, or tissues interact with engineered surfaces, particles, probes, or sensors that generate measurable optical, electrical, or chemical signals. Biospec-nano methods can improve the detection of biomarkers, characterization of molecular interactions, imaging, and analysis of limited or complex samples. Their applications support disease research, diagnostics, drug development, and bioengineering by enabling sensitive measurements at cellular and molecular scales.

Biospec-nano - Related Videos

Research

JoVE Journal - Biology

Fluorescence Imaging with One-nanometer Accuracy (FIONA)

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Cited by 11 •

2014

Single fluorophores can be localized with nanometer precision using FIONA. Here a summary of the FIONA technique is reported, and how to carry out FIONA experiments is described.

Research

JoVE Journal - Engineering
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Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

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Cited by 40 •

2016

We present a method for achieving sub-nanometer resolution images with amplitude-modulation (tapping mode) atomic force microscopy in liquid. The method is demonstrated on commercial atomic force microscopes. We explain the rationale behind our choices of parameters and suggest strategies for resolution optimization.

Research

JoVE Journal - Engineering
Free Sample

Measuring Sub-23 Nanometer Real Driving Particle Number Emissions Using the Portable DownToTen Sampling System

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Cited by 6 •

2020

Presented here is the DownToTen (DTT) portable emission measurement system to assess real driving automotive emissions of sub-23 nm particles.

Research

JoVE Journal - Engineering
Free Sample

Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope

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Cited by 5 •

2018

We use an aberration-corrected scanning transmission electron microscope to define single-digit nanometer patterns in two widely-used electron-beam resists: poly (methyl methacrylate) and hydrogen silsesquioxane. Resist patterns can be replicated in target materials of choice with single-digit nanometer fidelity using liftoff, plasma etching, and resist infiltration by organometallics.

Studying Soft-matter and Biological Systems over a Wide Length-scale from Nanometer and Micrometer Sizes at the Small-angle Neutron Diffractometer KWS-2

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Cited by 33 •

2016

Here, we present a protocol to investigate soft matter and biophysical systems over a wide mesoscopic length scale, from nm to µm that involves the use of the KWS-2 SANS diffractometer at high intensities and an adjustable resolution.

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