Bone Marrow Transplants
Bone Marrow Transplants - Related Videos
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Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
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Cited by 2 •
2012
Bone marrow transplantation provides a way to change the genotype of the bone marrow derived cells. If the gene of interest is expressed in both bone marrow derived cells and non-bone marrow derived cells, bone marrow transplantation can change the bone marrow derived cells to a different genotype without changing the non-bone marrow derived cell genotype.
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Bone Marrow Sampling and Transplants
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2024
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers. The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
08:42
Transplantation of Whole Kidney Marrow in Adult Zebrafish
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Cited by 17 •
2007
In this article, we demonstrate a method to perform HCT in adult zebrafish.
03:56
Bone Marrow Aspiration: A Method to Obtain Bone Marrow to Examine Cell Morphology
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2023
This video describes the technique of aspirating bone marrow from iliac spine and smear preparation for biopsy. In the example, we perform bone marrow aspiration from an acute myeloid leukemia (AML) patient and examine the cells to check for measurable residual disease (MRD), an important prognostic biomarker.
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Induction of Graft Versus Host Disease in Mouse Models via Allogeneic Bone Marrow and Splenic Cell Transplantation
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2025
This video demonstrates the induction of intestinal graft-versus-host disease, GvHD, in a lethally-irradiated recipient mouse using allogeneic hematopoietic stem cells and GvHD-inducing splenic alloreactive T lymphocytes. This protocol helps establish a severe acute intestinal GvHD model to understand the mechanism of the disease and develop innovative therapeutic options.
FAQs
These preparative treatments serve two purposes described in the transplant process: they eliminate abnormal cells and suppress the patient’s existing marrow. This creates conditions in which infused hematopoietic stem cells can establish themselves. The intensity and combination of treatment are therefore central biological variables because they influence how effectively diseased marrow is removed and new blood formation can begin.
After infusion, hematopoietic stem cells move to the bone marrow and engraft, meaning they establish a functioning blood-forming population there. Through stem-cell renewal and blood-cell production, this population generates red blood cells, platelets, and immune cells. The process links cellular biology with recovery of oxygen transport, clotting capacity, and immune-system function.
An autologous transplant returns the patient’s own collected stem cells, whereas an allogeneic transplant introduces cells from a compatible donor. This distinction changes the immune context of recovery. Donor-derived cells can provide an immune response against malignant cells, while the patient’s own cells do not provide that same donor-mediated immune contribution.
The process begins with selecting an appropriate stem-cell source, either the patient or a compatible donor. The patient then receives chemotherapy, radiation, or both to remove abnormal cells and suppress existing marrow. Finally, the stem cells are infused, after which they must reach the marrow and engraft so blood-cell production can resume.
The overview identifies leukemia, lymphoma, aplastic anemia, and certain inherited blood diseases as major applications. These conditions differ in their underlying problems, but transplantation addresses them by replacing damaged or diseased blood-forming tissue with healthy hematopoietic stem cells. The intended biological result is restoration of marrow activity and, consequently, production of blood and immune cells.
Bone marrow transplantation provides a biological model for studying how hematopoietic stem cells renew themselves and generate multiple blood-cell types. It also demonstrates that immune function can be rebuilt after existing marrow is suppressed. In allogeneic procedures, donor cells add another layer of immune regulation because their response may act against malignant cells.