Cadherin Seven
Cadherin Seven - Related Videos
01:25
Structure of Cadherins
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2023
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
01:19
Cadherins in Tissue Organization
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2023
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues. Cell Sorting During Development Cell sorting plays an...
04:42
Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic Flies
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2016
Herein we describe a procedure to capture live images of Drosophila gastrulation. This has enabled us to better understand the apical constriction involved in early development and further analyze mechanisms governing cellular movements during tissue structure modification.
11:31
Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Cited by 5 •
2017
Intercellular junctions are requisites for mammary gland stage-specific functions and development. This manuscript provides a detailed protocol for the study of protein-protein interactions (PPIs) and co-localization using murine mammary glands. These techniques allow for the investigation of the dynamics of the physical association between intercellular junctions at different developmental stages.
![Development and Characterization of <em>In Vitro</em> Microvessel Network and Quantitative Measurements of Endothelial [Ca<sup>2+</sup>]<sub>i </sub>and Nitric Oxide Production](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F54014.jpg%3Fv%3D2026-09-01%252006%253A38%253A51&w=750&q=75)
09:39
Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production
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Cited by 7 •
2016
Primary human umbilical vein endothelial cells (HUVECs) were grown to confluence within a microfluidic network device. The endothelial cell junction and F-actin distributions were illustrated and the changes in intracellular calcium concentration and nitric oxide production in response to adenosine triphosphate (ATP) were quantified in real-time at individual cell levels.
FAQs
Calcium ions support the structure of the extracellular cadherin repeats, allowing the adhesive region to maintain the configuration needed for interactions between neighboring cell surfaces. This dependence links adhesion strength and organization to the local calcium environment. In developing tissues, such regulation helps cells remain associated in appropriate groups while still participating in controlled rearrangements.
Homophilic binding occurs when cadherin-7 molecules on opposing cells interact with one another. This molecular preference can help cells with related adhesion properties associate selectively rather than distributing randomly. As a result, differences in adhesion can contribute to cell sorting, tissue boundaries, and the organized arrangement of cell populations during development.
The intracellular region links cadherin-7 adhesion sites to the cytoskeleton through catenin-associated complexes. This connection gives cells a structural route for coordinating contacts with changes in shape and movement. Consequently, adhesion is not an isolated surface event; it can influence how groups of cells maintain architecture while migrating or assembling into specialized tissues.
Changes in cadherin-7-mediated adhesion can alter how neural crest cells remain associated, separate into groups, or move through developing tissues. Because migration depends on coordinated cell behavior, either excessive persistence of contacts or insufficient cohesion could change cell segregation and positioning. Studying these effects helps connect molecular adhesion mechanisms with neural crest developmental patterns.
Craniofacial patterning depends on the ordered movement and assembly of developing cell populations. Cadherin-7 provides a molecular link between selective adhesion, cell sorting, and the organization of those populations. Changes in its activity can therefore be examined as potential explanations for altered tissue arrangement, migration paths, or formation of specialized craniofacial structures.
Investigations can evaluate whether changes in cadherin-7 activity affect cell segregation, coordinated movement, tissue architecture, or assembly into specialized structures. These outcomes connect molecular interactions at cell surfaces with larger developmental processes. In biology, the protein is especially informative when researchers examine how neural crest behavior contributes to craniofacial organization.