Greater Omentum
Greater Omentum - Related Videos
03:18
Modeling Ovarian Cancer Cell Colonization of Omentum: An Ex Vivo Method to Establish Milky Spot Colonization of Fluorescently Labeled Ovarian Cancer Cells in Murine Omentum Explants
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2023
In this video, we establish an ex vivo omental organ culture overlaid with GFP-expressing ovarian cancer cells to study ovarian cancer colonization within the omental explant. This protocol analyzes immune cell structures within the omentum known as milky spots that promote metastases.
04:36
Mesothelial Cell Isolation: A Technique to Isolate Primary Mesothelial Cells From Human Omentum Tissue Specimen
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2023
This video describes the protocol to isolate primary human mesothelial cells from the human omentum specimen. The mesothelial cells can be used to establish an in vitro ovarian cancer model to investigate ovarian cancer cell adhesion, invasion, and proliferation.
06:25
A Method for Islet Transplantation to the Omentum in Mouse
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Cited by 4 •
2019
A method for the omental transplantation of islets in a mouse is introduced. The isolated islets are mixed with hydrogel and the mixture is placed into the omental pouch of a diabetic mouse. Then, the blood glucose is monitored, and immuno-histochemical analysis is performed.
05:42
An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum
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2024
This protocol describes the establishment of a three-dimensional (3D) ex vivo model of cancer cell-omentum interaction. The model provides a platform for elucidating pro-tumor mechanisms within the adipose niche and for testing novel therapies.
09:00
Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity
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Cited by 20 •
2015
Here, we present a protocol to construct a three-dimensional in vitro model of the lining of the peritoneal cavity, composed of primary human mesothelial cells and fibroblasts layered with extracellular matrix, as a tool to investigate ovarian cancer cell adhesion, invasion, and proliferation.
FAQs
Its mobility allows it to shift toward sites of inflammation or tissue damage within the peritoneal cavity. After reaching an affected area, it can adhere to the site, helping localize infection or injury rather than allowing the problem to spread freely. This behavior links its anatomy with a protective role in abdominal tissue repair.
These components give the greater omentum structural support while enabling transport and surveillance within abdominal tissues. Connective tissue forms its layered framework, blood vessels contribute to vascular supply, and lymphatic channels support immune-related functions. Their combination helps explain how the tissue can respond dynamically to injury while remaining integrated with surrounding organs.
The greater omentum contributes to immune surveillance by positioning immune-related tissue and lymphatic channels within the peritoneal cavity. This arrangement supports recognition and localization of inflammatory events, complementing its tendency to adhere to affected areas. Consequently, the tissue functions not only as a physical covering but also as part of the abdomen’s local protective response.
Adipose tissue adds a storage function to the greater omentum and contributes to variation in its composition among individuals. Because the tissue also contains connective structures, vessels, and lymphatic channels, its adipose component exists within a multifunctional anatomical framework. This combination makes the greater omentum relevant to both abdominal protection and research on metabolic disease.
Its ability to move, adhere to injured regions, and contribute to vascular supply makes the greater omentum relevant to abdominal surgery and transplantation. These properties help explain why clinicians and researchers consider its anatomy when evaluating damaged or reconstructed abdominal tissues. Its layered structure and connections with nearby organs also provide important biological context for operative planning and tissue repair.
The greater omentum provides a model for investigating how inflammation becomes localized, how tissues support wound healing, and how vascular and lymphatic features contribute to abdominal protection. Its variable adipose content also connects it with metabolic disease research. Studies can therefore examine both local tissue responses and broader relationships among fat storage, immunity, and repair.