Mouse Il-17 Secreting Cells
Mouse Il-17 Secreting Cells - Related Videos
12:38
Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
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2008
This procedure describes the detection and isolation of mouse TH17 leukocytes that actively secrete IL-17 upon stimulation.
01:16
Cells and Secretions of the Pancreas
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2024
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels. Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices. Concurrently, the dispersed clusters of endocrine cells throughout the...
04:20
Functional Assessment of Antibody-Secreting B Cells Using ELISpot Assay
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2025
This video demonstrates the use of the ELISpot assay to assess the function of antibody-secreting B cells, ASCs. The antibodies secreted by the ASCs interact with the membrane-bound polyclonal antibody fragments, which are detected by the enzyme-conjugated IgG or IgM antibodies. The colored spot produced in each well indicates the presence of the specific antibody's isotype, which correlates with the B cells' secretory activity.
09:09
A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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Cited by 5 •
2015
Inter-cellular communication is critical for controlling various physiological activities within and outside the cell. This paper describes a protocol for measuring the spatio-temporal nature of single cell secretions. To achieve this, a multidisciplinary approach is used which integrates label-free nanoplasmonic sensing with live cell imaging.
11:42
Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
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Cited by 11 •
2017
This work describes a fluorescence microscopy-based method for the study of platelet adhesion, spreading, and secretion under flow. This versatile platform enables the investigation of platelet function for mechanistic research on thrombosis and hemostasis.
FAQs
Activation can follow exposure to antigen, cytokines, or other immune signals, rather than a single universal trigger. These inputs stimulate the cells to release IL-17, allowing investigators to examine how different immune contexts shape cytokine production. Comparing activation conditions can connect upstream immune signaling with downstream inflammatory or host-defense responses.
After release, IL-17 binds receptors on target tissues and promotes production of chemokines and other mediators. Those tissue-derived signals help recruit and activate additional immune cells, extending the response beyond the original secreting population. This mechanism links cytokine production by mouse cells to coordinated local inflammation and host defense.
The same inflammatory activity can support host defense while also contributing to tissue inflammation, depending on the biological setting. IL-17-driven chemokine and mediator production may help organize immune-cell recruitment, but excessive or misdirected responses can be relevant to autoimmune inflammation. Mouse studies help distinguish beneficial defense from disease-associated tissue responses.
These cells provide an experimental system for examining how T-cell differentiation relates to IL-17 production and immune activity at mucosal sites. Their behavior can be studied alongside responses to infection or other immune signals, helping clarify how cellular specialization contributes to protective barriers, inflammatory regulation, and tissue-specific host defense.
Researchers can vary the activating context, including antigen, cytokines, or other immune signals, and then examine IL-17 release and the resulting tissue-response pathways. Comparing these conditions helps identify which inputs favor inflammatory or host-defense programs. The approach also connects cellular activation with chemokine production and immune-cell recruitment in downstream tissues.
They support studies of infection, autoimmune inflammation, mucosal immunity, and tissue responses, while also providing context for investigating T-cell differentiation. Researchers can ask whether IL-17 activity accompanies protection, disease, or altered tissue signaling. The system is also useful for evaluating experimental therapies designed to modify inflammatory pathways and their consequences.