Myelinated Axons
Myelinated Axons - Related Videos
04:33
Fluorescence Photoactivation Imaging of Neurofilament Transport in Myelinated Mouse Axons
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2025
Source: Boyer, N. P. et. al., Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve. J. Vis. Exp. (2020) This video demonstrates the fluorescence photoactivation method to analyze neurofilament transport in myelinated axons of peripheral nerves. By tracking photoactivated green fluorophore-tagged neurofilaments, the technique provides insights into axonal transport in neurodegenerative diseases.
04:16
Using Spectral Reflectometry to Determine Myelinated Axon Diameters in a Fixed Mouse Brain Slice
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2025
Source: Kwon, J., et al., Spectral Reflectometric Microscopy on Myelinated Axons In Situ. J. Vis. Exp. (2018) This video demonstrates the use of spectral reflectometry with a hyperspectral confocal microscope to analyze interference patterns and determine myelinated axon diameters in fixed brain tissue slices.
09:13
Spectral Reflectometric Microscopy on Myelinated Axons In Situ
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Cited by 1 •
2018
Here, we present a step-by-step protocol for imaging myelinated axons in a fixed brain slice using a label-free nanoscale imaging technique based on spectral reflectometry.
01:23
A Gold Staining Technique to Visualize Myelin Reduction in Stressed Mice
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2025
Stress impairs oligodendrocyte function, disrupting the lipid-rich myelin sheath surrounding neuronal axons in the medial prefrontal cortex, a brain region regulating emotion.
02:11
Co-culturing of a Dorsal Root Ganglion Explant with Schwann Cells for Neuron Myelination
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2025
This video demonstrates the coculturing model of a dorsal root ganglion explant and Schwann cells. In coculture conditions, ascorbic acid promotes the differentiation of Schwann cells into myelinating forms. Myelinating Schwann cells wrap the axons multiple times to create a myelin sheath, which is essential for nerve function.
FAQs
Nodes of Ranvier provide exposed interruptions between insulated segments, allowing electrical impulses to move from node to node rather than continuously along the entire axon surface. This saltatory pattern helps signals travel rapidly and efficiently, while the organized spacing of nodes supports reliable communication between neurons and their targets.
The nervous system uses different supporting cells to produce myelin in its two major regions. Oligodendrocytes provide myelin in the central nervous system, whereas Schwann cells do so in the peripheral nervous system. This distinction helps researchers relate changes in axonal insulation to the specific neural region affected.
By insulating much of the axon, myelin limits the amount of membrane that must participate directly in electrical signaling. Impulses are renewed at exposed nodes instead of across the full length of the fiber. This arrangement supports rapid transmission while reducing the energetic cost of maintaining neural communication.
Myelinated axons help coordinate communication across neural pathways involved in sensing, movement, and cognition. Their efficient signaling allows information to travel through the nervous system with appropriate speed and timing. Disruption of this organization can therefore affect communication between neurons and interfere with several types of nervous-system function.
Research on myelinated axons clarifies how neural signals move through the nervous system and how cellular organization supports efficient communication. It also provides a framework for examining what happens when insulation is lost or axons are injured. These findings connect basic neural signaling with broader questions about nervous-system performance.
Their structure gives researchers a way to investigate disorders and injuries that impair neural communication. Studying the myelin sheath, its producing cells, and node-to-node signaling can help explain why disrupted insulation affects information transfer. This context is relevant to understanding demyelination, nerve injury, and resulting sensory, motor, or cognitive problems.