Primitive Heart Tube
Primitive Heart Tube - Related Videos
09:23
Preparation of embryos for Electron Microscopy of the Drosophila embryonic heart tube
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Cited by 7 •
2009
We describe a process for fixation, embedding, sectioning, and imaging of late stage Drosophila embryos for Trasmission Electron Microscopy of the embryonic heart tube. This technique allows for the visualization of the heart tube lumen as well as the basement membrane, which lines the lumen of the heart.
14:37
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Cited by 19 •
2017
Here, we present human pluripotent stem cell (hPSC) culture protocols, used to differentiate hPSCs into CD34+ hematopoietic progenitors. This method uses stage-specific manipulation of canonical WNT signaling to specify cells exclusively to either the definitive or primitive hematopoietic program.
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
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Cited by 40 •
2014
This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.
10:56
Tube Thoracostomy
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2023
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Tube thoracostomy (chest tube placement) is a procedure during which a hollow tube is inserted into the thoracic cavity for drainage of fluid or air. Emergency chest tube insertion is performed for definitive treatment of tension pneumothorax, traumatic hemothorax, large-volume pleural effusions, and empyemas. Irrespective of the cause of air and fluid accumulation in the pleural space, the...
07:47
A Novel Ex vivo Culture Method for the Embryonic Mouse Heart
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Cited by 12 •
2013
Developmental studies in the mouse are hampered by the inaccessibility of the embryo during gestation. To promote the long-term culture of the embryonic heart at late stages of gestation, we developed a protocol in which the excised heart is cultured in a semi-solid, dilute Matrigel.
FAQs
Its formation follows a coordinated sequence rather than a single event. Cardiogenic mesoderm first differentiates into cardiac cells, then the two bilateral fields migrate toward the midline and fuse. This progression connects tissue specification with physical assembly, allowing the newly formed tube to contract rhythmically and create an early route for circulating blood.
Looping and regional specialization transform the initial tube arrangement into a developing plan for future chambers and vessels. These changes are important because the first tube is transient: its later remodeling links early heart formation with the spatial organization needed for subsequent cardiac function and blood circulation.
Because the primitive heart tube begins rhythmic contraction, it provides an early connection between cardiac patterning and blood flow. Its activity occurs while the heart is still being organized, so the structure offers a way to consider how morphogenesis, the formation of cardiac shape, and circulation are coordinated during embryonic development.
Its developmental sequence connects mesoderm differentiation, cell migration, midline fusion, tube contraction, looping, and regional specialization. Examining these linked events can help researchers identify where cardiac patterning may diverge from the expected pathway. That makes the primitive heart tube a framework for investigating how congenital heart defects arise during development.
In experimental models, researchers can use the primitive heart tube as a developmental reference for evaluating effects on embryonic heart formation. The model is especially informative when a study concerns the timing and coordination of cardiac cell differentiation, migration, fusion, contraction, and later structural organization.
Analysis of the primitive heart tube can provide insight into how early cardiac patterning relates to blood flow and heart morphogenesis. Because the structure appears before definitive chambers and vessels are established, it offers a developmental framework for connecting early cellular events with the later organization of the vertebrate heart.