Salivary Gland

Salivary glands are exocrine organs that produce and release saliva into the mouth, where it supports digestion, lubrication, taste, and oral health. Acinar cells secrete a fluid containing water, electrolytes, mucus, and digestive enzymes, while duct cells modify its ionic composition as it moves through glandular ducts; autonomic nerve signals regulate secretion in response to stimuli such as food. In biology and medicine, studying the major glands, including the parotid, submandibular, and sublingual glands, helps explain oral function and disorders such as dry mouth, inflammation, obstruction, and tumors. Salivary gland research also supports noninvasive approaches to disease monitoring and regenerative medicine.

Salivary Gland - Related Videos

Research

JoVE Journal - Biology
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Dissection of Midgut and Salivary Glands from Ae. aegypti Mosquitoes

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Cited by 58 •

2007

The mosquito midgut and salivary glands are key entry and exit points for vector pathogens like Plasmodium falciparum and the dengue virus. This video demonstrates the dissection techniques for removing the midgut and salivary glands from Aedes aegypti mosquitoes.

Research

JoVE Journal - Medicine

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

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Cited by 17 •

2011

A protocol for the cannulation of the mouse submandibular salivary gland via the Wharton's duct is described. For this experiment, the trypan blue solution is used as a dyer to demonstrate how this technique effectively delivers infusions into the targeted gland, and to suggest the reliability of this new approach as a potential clinical drug/cell therapy for the regeneration of salivary glands.

Culturing Salispheres from Salivary Gland Tissue: A Method to Develop Salispheres from Human Salivary Gland Derived Epithelial Cells

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2023

This video presents the protocol for culturing salispheres, the three-dimensional spheroids derived from salivary glands. The salispheres can be further used to assess the impact of head and neck cancer on saliva production from salivary glands of affected human patients.

Saliva, Salivary Gland, and Hemolymph Collection from Ixodes scapularis Ticks

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Cited by 75 •

2012

The collection of infected tick hemolymph, salivary glands, and saliva is important to study how tick-borne pathogens cause disease. In this protocol we demonstrate how to collect hemolymph and salivary glands from feeding Ixodes scapularis nymphs. We also demonstrate saliva collection from female I. scapularis adults.

Genetic Modification and Recombination of Salivary Gland Organ Cultures

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Cited by 20 •

2013

A technique to genetically manipulate epithelial cells within whole ex vivo cultured embryonic mouse submandibular glands (SMGs) using viral gene transfer is described. This method takes advantage of the innate ability of SMG epithelium and mesenchyme to spontaneously recombine after separation and infection of epithelial rudiments with adenoviral vectors.

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