Pathogen Transmission

Pathogen transmission is the movement of infectious agents, including viruses, bacteria, fungi, and parasites, between hosts or from the environment to a host. It occurs through routes such as direct contact, respiratory droplets or aerosols, contaminated food and water, contaminated surfaces, and biological vectors, with transmission shaped by pathogen biology, host susceptibility, and environmental conditions. Biologists investigate these pathways using epidemiological data, laboratory models, and surveillance to determine how infections spread through populations. This knowledge supports infection-control measures, vaccination strategies, risk assessment, and public-health interventions that reduce disease transmission and improve outbreak preparedness.

Pathogen Transmission - Related Videos

Education

JoVE Core - Microbiology

Transmission of Pathogens

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2026

Pathogens spread from their reservoirs to susceptible hosts through three main routes: contact transmission, vehicle transmission, and vector transmission. Each route involves distinct mechanisms of transfer.Contact TransmissionThis category includes direct contact, indirect contact, and droplet transmission:Direct contact involves immediate physical interaction between individuals—such as a handshake—which can spread pathogens like Streptococcus pyogenes, the bacterium responsible for...

Research

JoVE Journal - Immunology and Infection
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Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

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Cited by 22 •

2013

We describe a method for tracking the endomembrane rupture elicited by the intracellular bacteria Shigella flexneri and Mycobacterium tuberculosis upon host cell invasion. Our assay makes use of CCF4, a host cytoplasmic FRET probe in live or fixed cells. This reporter is degraded by an enzyme activity present on the bacterial surface.

Research

JoVE Journal - Environment
Free Sample

Detection of Foodborne Bacterial Pathogens from Individual Filth Flies

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Cited by 20 •

2015

A PCR-based protocol was adapted to detect Cronobacter spp., Salmonella enterica, and Listeria monocytogenes from body surfaces and alimentary canals of individual wild-caught flies. The goal of this protocol is to detect and isolate bacterial pathogens from individual insects collected as part of an environmental sampling program during foodborne outbreak investigations.

Non-invasive Assessment of Changes in Corticomotoneuronal Transmission in Humans

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Cited by 6 •

2017

The aim of the present study was to assess changes in transmission at the corticomotoneuronal synapses in humans after repetitive transcranial magnetic stimulation. For this purpose, an electrophysiological method is introduced that allows assessment of pathway specific corticospinal transmission, i.e. differentiation of fast, direct corticospinal pathways from polysynaptic connections.

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants

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Cited by 20 •

2008

This video demonstrates how to employ two neural stimulants, aldicarb and pentylenetetrazole (PTZ), in complementary ways to study synaptic function in the nematode, C. elegans. This complementary approach may also be used to shed light on evolutionarily conserved mechanisms for modulating neuronal synchrony and has implications for epilepsy and seizures.

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