Transbronchial Cryobiopsy
Transbronchial Cryobiopsy - Related Videos
04:10
Robotic-assisted Bronchoscopy Combined with Multimodal Imaging for Targeted Lung Cryobiopsies
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Cited by 1 •
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This article aims to describe a stepwise approach to performing robotic-assisted bronchoscopy combined with fluoroscopy, radial endobronchial ultrasound, and cone beam computed tomography to obtain targeted transbronchial lung...
10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Substernal thyroid lesions are common, and need to be differentiated from malignancy. Obtaining percutaneous fine needle biopsy is not possible due to its retrosternal location. This article proposes a protocol for biopsy of substernal thyroid lesions using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA).
09:01
The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
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This article describes bronchoscopic techniques in the bovine lung under experimental conditions, i.e. bronchoscopically guided inoculation, bronchoalveolar lavage, bronchial brushing, and transbronchial lung biopsy.
14:21
Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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A method to image ex vivo pulmonary resection specimens with optical frequency domain imaging (OFDI) and obtain precise correlation to histology is described, which is essential to developing specific OFDI interpretation criteria for pulmonary pathology. This method is applicable to other tissue types and imaging techniques to obtain precise imaging to histology correlation for accurate image interpretation and assessment. Imaging criteria established with this technique would then be...
06:03
Use of Electromagnetic Navigational Transthoracic Needle Aspiration (E-TTNA) for Sampling of Lung Nodules
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We describe the novel use of electromagnetic navigational guided transthoracic needle aspiration for the pathologic assessment of human lung nodules.
FAQs
Rapid gas expansion cools the flexible cryoprobe to an extreme temperature. Tissue adjacent to the probe freezes and adheres to its surface, allowing the attached specimen to be extracted through the bronchoscope. This freeze-and-adhere mechanism supports recovery of relatively large lung samples, which is important when researchers need more tissue for detailed examination.
Compared with conventional forceps biopsy, Transbronchial Cryobiopsy can produce larger specimens with less crush artifact. Crush artifact is physical distortion caused by tissue compression, and it can interfere with histopathological evaluation. Reducing this distortion may help investigators assess lung tumor structure more accurately and interpret tissue features that are important for distinguishing malignant from nonmalignant lesions.
Well-preserved tissue supports both histopathological evaluation and molecular analysis. Histopathology examines the structural features of tissue, while molecular analysis investigates biological characteristics relevant to tumor behavior. Obtaining a specimen suitable for both approaches can help connect visible tumor changes with underlying biology, strengthening studies of lung cancer classification, biomarkers, and potential targeted therapies.
The procedure places a flexible cryoprobe through a bronchoscope and positions it near the area requiring sampling. Rapid gas expansion then freezes nearby tissue, causing it to adhere to the probe. The probe and attached sample are subsequently extracted. This sequence is designed to recover a relatively large, preserved lung specimen for diagnostic or research evaluation.
The larger, relatively well-preserved samples can provide material for examining tumor biology in greater detail. Researchers may use the tissue to evaluate structural features, distinguish malignancy from other pulmonary lesions, and investigate molecular characteristics. These capabilities make the technique relevant to cancer research focused on understanding tumor diversity and identifying findings that may guide further study.
Samples obtained through Transbronchial Cryobiopsy can contribute to research on biomarkers and targeted therapies. Biomarker studies seek measurable tumor characteristics associated with disease classification or biological behavior, while targeted-therapy research examines treatment approaches directed at specific tumor features. The same specimens can also support broader investigations into how lung tumors develop and differ from other pulmonary lesions.