Carboxymethyl Prefix

The carboxymethyl prefix is a chemical nomenclature term that identifies a substituent containing a methylene group attached to a carboxylic acid group, written as –CH₂COOH. In a parent structure, the prefix indicates that this unit is bonded through its methylene carbon, while the carboxyl group can release a proton, form salts, and participate in hydrogen bonding. Recognizing carboxymethyl groups helps chemists interpret the structures and properties of compounds such as carboxymethyl cellulose and carboxymethylated chelating agents. Their presence can increase polarity, aqueous solubility, and opportunities for ionic or coordination interactions, supporting applications in materials chemistry, formulation, and analytical research.

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JoVE Journal - Neuroscience

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Cited by 2 •

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This protocol describes a rapid and simplified in situ hybridization method ideal forparaformaldehyde-prefixed brain, thus reducing the need for prolonged complex steps while using fresh frozen tissues. The method is validated using the identification of the serotonin 5-HT2A receptor gene htr2a in rats.

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JoVE Core - Chemistry

Molecular Compounds: Formulas and Nomenclature

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2020

Molecular compounds or covalent compounds result when atoms share electrons to form covalent bonds. Since there is no electron transfer, molecular compounds do not contain ions; instead, they consist of discrete, neutral molecules. Since covalent compounds are formed from the combination of nonmetals, the periodic table can help recognize many of them. The position of a compound’s elements in the periodic table can predict whether the compound is ionic or covalent (although there are...

Coordination Compounds and Nomenclature

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2020

In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...

Ionic Compounds: Formulas and Nomenclature

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2020

An element composed of atoms that readily lose electrons (a metal) can react with an element composed of atoms that readily gain electrons (a nonmetal) to produce ions through complete electron transfer. The compound formed by this transfer is stabilized by the electrostatic attractions (ionic bonds) between the oppositely charged ions. Moving from the far right to the left on the periodic table, nonmetal elements often gain electrons to form anions with the same number of electrons as an atom...

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Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

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Cited by 9 •

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This manuscript uses the Fiji-based open-source software package VirusMapper to apply single-particle analysis to super-resolution microscopy images in order to generate precise models of nanoscale structure.

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