Lipid Deposition
Lipid Deposition - Related Videos
10:34
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
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Cited by 3 •
2017
We present a protocol to functionalize glass with nanometric protein patches surrounded by a fluid lipid bilayer. These substrates are compatible with advanced optical microscopy and are expected to serve as platform for cell adhesion and migration studies.
02:33
Phase Transitions: Sublimation and Deposition
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2020
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
03:38
Structure of Lipids
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2020
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
08:23
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
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Cited by 4 •
2016
We demonstrate a storable, transportable lipid bilayer formation system. A lipid bilayer membrane can be formed within 1 hr with over 80% success rate when a frozen membrane precursor is brought to ambient temperature. This system will reduce laborious processes and expertise associated with ion channels.
10:52
Formation of Thick Dense Yttrium Iron Garnet Films Using Aerosol Deposition
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Cited by 7 •
2015
This report describes the use of a custom-built system to perform aerosol deposition of thick films of yttrium iron garnet onto sapphire substrates at RT. The deposited films are characterized using scanning electron microscopy, profilometry, and ferromagnetic resonance to give a representative overview of the capabilities of the technique.
FAQs
Accumulation becomes more likely when lipid uptake or synthesis outpaces oxidation, transport, or removal. This imbalance allows lipid molecules to persist within cells, tissues, or extracellular structures rather than being cleared or metabolized. The resulting buildup can progressively change local anatomy and interfere with normal function, making the balance among these processes central to disease development.
Modified low-density lipoprotein can enter the arterial wall and stimulate macrophages to take it up. As these immune cells accumulate lipid, they become foam cells, creating a lipid-rich component within the developing plaque. This sequence links altered circulating lipoprotein, cellular uptake, and structural change in the vessel to atherosclerotic plaque development.
The clinical effect depends on where lipid accumulates and which structures are altered. In blood vessels, buildup contributes to atherosclerotic plaques; in the liver, it is associated with fatty liver disease; and in storage disorders, accumulation reflects a different disease context. Thus, location helps determine both the functional consequences and the relevant underlying mechanism.
Assessment should address both the distribution of accumulated lipid and its likely cause. Mapping where deposition occurs can clarify which tissues or structures are affected, while examining the balance of uptake, synthesis, oxidation, transport, and removal can indicate the processes driving it. Together, these observations help relate a structural finding to disease progression and mechanism.
Changes in the amount or distribution of accumulated lipid can provide information about whether a disease process is advancing and which tissues remain involved. In clinical research, these observations are interpreted alongside possible metabolic or inflammatory drivers. This approach helps distinguish a localized structural change from a broader process that may require continued monitoring or mechanistic investigation.
Lipid deposition offers a measurable disease-related outcome for studying whether an intervention affects accumulation or its underlying drivers. Researchers can examine changes in distribution and connect them with metabolic or inflammatory mechanisms. In conditions such as atherosclerotic plaque development or fatty liver disease, this information supports evaluation of therapeutic strategies aimed at altering disease progression.