Constrictive Pericarditis

Constrictive pericarditis is a chronic condition in which a thickened, scarred, or calcified pericardium restricts the heart’s normal expansion and impairs diastolic filling. Loss of pericardial compliance causes ventricular interdependence, so pressure changes during respiration alter right- and left-sided filling and produce systemic venous congestion. In clinical practice, recognizing this mechanism helps distinguish constriction from restrictive cardiomyopathy and other causes of heart failure with preserved ejection fraction through physical examination, echocardiography, cardiac imaging, and hemodynamic assessment. Management focuses on treating reversible causes when possible, while pericardiectomy may provide definitive relief for persistent symptomatic constriction.

Constrictive Pericarditis - Related Videos

Research

JoVE Journal - Biology

Transverse Aortic Constriction in Mice

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Cited by 263 •

2010

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model to study mechanisms underlying cardiac hypertrophy and heart failure development. Here, we describe procedures to constrict the aorta to create a reproducible degree of cardiac hypertrophy in mice.

Education

JoVE Core - Medical-Surgical Nursing

Pericarditis I: Introduction

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2025

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

Minimally Invasive Transverse Aortic Constriction in Mice

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Cited by 42 •

2017

Minimally invasive transverse aortic constriction (MTAC) conserves the essentials of regular transverse aortic constriction (TAC) while eliminating the use of a ventilator with tracheal intubation. It proves to be a highly desirable method for high-throughput studies on left ventricular overload, particularly in translational studies.

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

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Cited by 26 •

2016

A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

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Cited by 151 •

2012

Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).

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