Echocardiography Infarction Size
Echocardiography Infarction Size - Related Videos
06:47
Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction
0 Views •
2025
This article details an optimized protocol for echocardiography-guided intramyocardial injections in rat models of myocardial infarction using a 29 G x 88 mm needle. This technique ensures robust, precise, and reproducible delivery of therapeutic agents directly into the peri-infarct zone.
09:45
Histological Quantification of Chronic Myocardial Infarct in Rats
0 Views •
Cited by 14 •
2016
The post-mortem assessment of myocardial infarction (MI) in rodents is based on quantification of the infarct on stained heart sections. We describe an accurate method to quantify the infarct size using systematic sampling of harvested rat hearts from base to apex and image analyses of trichrome-stained histological sections.
07:48
Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
0 Views •
Cited by 37 •
2016
This protocol describes a highly reproducible model of cardiac regeneration by surgical induction of myocardial infarction in the left ventricle of postnatal day 1 mice. The method involves induction of hypothermic anesthesia and ligation of the left anterior descending coronary artery.
14:19
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
0 Views •
Cited by 13 •
2016
Reliable and accurate outcome assessment is the key for translation of preclinical therapies into clinical treatment. The current paper describes how to assess three clinically relevant primary outcome parameters of cardiac performance and damage in a pig acute myocardial infarction model.
08:09
Transthoracic Echocardiography in Mice
0 Views •
Cited by 81 •
2010
Transthoracic echocardiography offers a noninvasive method for the evaluation of cardiac function in mice. A combination of ultrasound and Doppler imaging modalities can be used to obtain dimensional measurements of the heart and intracardiac blood flow, which together provide an assessment of cardiac systolic and diastolic performance.
FAQs
Regional wall-motion abnormalities provide functional evidence of injury by showing how specific myocardial areas contract after ischemic damage. Examining these changes alongside ventricular dimensions and overall contractile function helps researchers relate localized dysfunction to the extent of infarct burden. This combined assessment is useful when studying how cardiac tissue structure and performance change after injury.
When contrast imaging is available, perfusion-related changes add information beyond cardiac motion and dimensions. They can indicate differences in blood delivery associated with injured myocardium, helping researchers interpret whether abnormal regions also show altered perfusion. Combining functional and perfusion observations may provide a more informative picture of ischemic injury and its progression.
Infarction burden does not describe cardiac performance by itself. Ventricular dimensions show structural changes, while contractile function indicates how effectively the heart or cardiac tissue responds mechanically. Considering these measures together helps distinguish the amount of damaged tissue from its functional consequences, which is important for evaluating remodeling and recovery after ischemic injury.
A study can acquire real-time ultrasound views, examine regional wall motion, record ventricular dimensions and contractile function, and include contrast-related perfusion observations when available. Repeating these measurements over time allows investigators to compare infarct burden with changing cardiac performance. The resulting longitudinal data can connect injury extent to recovery or post-injury remodeling.
In developmental biology, echocardiographic measurements can characterize how developing or engineered cardiac tissues respond to ischemic injury. Researchers can track regional motion, structural dimensions, and contractile behavior as the tissue matures or repairs itself. These observations help relate developmental state to injury response and reveal functional changes that occur during recovery.
Repeated assessments support studies of cardiac maturation, tissue repair, regenerative therapies, and mechanisms of post-injury remodeling. By following infarct burden and functional outcomes over time, researchers can examine whether cardiac tissue recovers, remains impaired, or changes structurally after ischemia. This approach also helps compare injury responses across developmental or engineered tissue models.