Animal Infection Model
Animal Infection Model - Related Videos
07:02
Animal Model of Implant-Associated Infections in Mice
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2025
The present protocol describes a mouse model employing subcutaneous dorsal implantation to investigate implant-associated infections, enabling comprehensive investigation of pathophysiological mechanisms and supporting the development of diagnostic criteria with targeted therapeutic strategies.
26:43
Computer-Generated Animal Model Stimuli
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Cited by 8 •
2007
Computer-generated stimuli using the Jacky dragon as a model.
09:03
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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Cited by 31 •
2012
Infection of mice with an Adenovirus expressing the major human autoantigen cytochrome P450 2D6 (hCYP2D6) recognized by sera of patients suffering from type 2 autoimmune hepatitis results in a persistent form of autoimmune-mediated liver disease characterized by extensive hepatitis, fibrosis and generation of a CYP2D6-specific immune response.
07:34
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Cited by 13 •
2012
Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection, and can be simulated by a surgical technique termed cecal ligation and puncture (CLP). Here we describe a method to use CLP-induced animal model to screen medicinal herbs for therapeutic agents.
12:30
Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
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Cited by 108 •
2013
The larva of the wax moth Galleria mellonella was recently established as an in vivo model to study Legionella pneumophila infection. Here, we demonstrate fundamental techniques to characterize the pathogenesis of Legionella in the larvae, including inoculation, measurement of bacterial virulence and replication as well as extraction and analysis of infected hemocytes.
FAQs
Species selection affects whether the host is susceptible to the chosen pathogen or microbial component and how clearly investigators can observe infection-related responses. It also influences the relevance of findings to human health. Matching the animal to the research question helps distinguish pathogen replication, tissue responses, clinical signs, and immune activity under controlled experimental conditions.
Innate and adaptive immune activity provides complementary information about host defense. Monitoring both can show how early responses relate to later immune activity and whether infection is associated with protective or disease-linked changes. Examining these responses alongside pathogen replication, tissue effects, and clinical signs helps investigators connect immune mechanisms with infection outcomes.
The infection route and dose are important experimental variables because they shape how the introduced pathogen or microbial component interacts with the susceptible host. Using defined conditions makes comparisons between animals or treatment groups more interpretable. These choices can influence pathogen replication, tissue responses, clinical signs, and the immune activity detected during sampling.
A study begins by selecting a susceptible animal and defining the pathogen or microbial component to be introduced. Investigators then establish the infection route, dose, controlled conditions, and sampling schedule. During the study, they monitor pathogen replication, tissue responses, clinical signs, and innate and adaptive immune activity to evaluate how infection develops.
Measurements from an animal infection model can link pathogen replication with tissue responses, clinical signs, and immune activity. This combination helps reveal mechanisms of host defense and immune-mediated disease rather than relying on a single outcome. A planned sampling schedule allows investigators to examine these features as infection progresses under controlled conditions.
These models support evaluation of vaccines, antimicrobial therapies, and diagnostic strategies by allowing investigators to examine responses in a living host. Outcomes may include changes in pathogen replication, tissue responses, clinical signs, or immune activity. Careful control of species, infection route, dose, and sampling schedule strengthens interpretation of whether an approach may inform human health.