Bubble Removal
Bubble Removal - Related Videos
01:13
Excess Pressure Inside a Drop and a Bubble
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2023
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops. where γ corresponds to the surface tension. Recalling that the force per...
08:19
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
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Cited by 2 •
2021
A fast and reliable technique is proposed to control the shape oscillations of a single, trapped acoustic bubble that is based on coalescence technique between two bubbles. The steady-state, symmetry-controlled bubble shape oscillations allow analysis of the fluid flow generated in the vicinity of the bubble interface.
06:43
Rotary Evaporation to Remove Solvent
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2023
Source: Dr. Melanie Pribisko Yen and Grace Tang — California Institute of Technology Rotary evaporation is a technique most commonly used in organic chemistry to remove a solvent from a higher-boiling point compound of interest. The rotary evaporator, or "rotovap", was invented in 1950 by the chemist Lyman C. Craig. The primary use of a rotovap is to dry and purify samples for downstream applications. Its speed and ability to handle large volumes of solvent make rotary evaporation a preferred...
07:18
Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
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Cited by 12 •
2019
Here, we present a protocol for the formation of lipid bilayers using a contact bubble bilayer method. A water bubble is blown into an organic solvent, whereby a monolayer is formed at the water-oil interface. Two pipettes are manipulated to dock the bubbles to form a bilayer.
11:14
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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Cited by 8 •
2017
A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.
FAQs
Trapped gas can interrupt continuous contact between a liquid and device surfaces, making reagent volumes less consistent and fluid movement less uniform. In immunology and infection experiments, those disruptions may affect how cells, pathogens, and assay components contact one another. Removing the gas therefore helps stabilize handling conditions, microscopy, and measurements rather than merely improving the device’s appearance.
Controlled priming, directed fluid flow, pressure changes, and degassing address gas in different ways, but their shared effect is to displace trapped gas or reduce dissolved gas. Once the liquid again maintains continuous contact with device surfaces, the system can handle samples more consistently. This mechanism is especially important when uniform flow or reliable imaging is required.
The overview distinguishes gas trapped within a system from gas dissolved in the liquid. Flow, priming, or pressure changes can displace gas from containers and fluidic pathways, whereas degassing targets gas held in the liquid itself. Recognizing this distinction helps match the quality-control approach to the source of instability and supports more consistent sample handling.
Begin by identifying whether the concern is gas trapped in the container or pathway, dissolved gas in the liquid, or both. Controlled priming and fluid flow can clear trapped spaces, while pressure changes or degassing provide additional ways to address gas. The selected approach should restore continuous liquid contact before samples, reagents, or assay components are evaluated.
Bubble removal is relevant to diagnostic assays, culture experiments, and microfluidic studies. It supports accurate reagent volumes in diagnostic work, stable flow in fluidic systems, and reliable microscopy when visual observations depend on an uninterrupted liquid environment. In infection and immunology research, these benefits help maintain more uniform contact among cells, pathogens, and assay components.
Useful improvements include more consistent reagent volumes, steadier fluid movement, and more reliable microscopy. At the study level, the process is expected to reduce measurement variability and improve reproducibility across diagnostic, culture, and microfluidic experiments. These outcomes make bubble removal a practical quality-control step for interpreting differences between samples rather than attributing handling artifacts to biology.