Neurobehavioral Impairments
Neurobehavioral Impairments - Related Videos
19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Cited by 40 •
2014
The NICU Network Neurobehavioral Scale (NNNS) was developed as an assessment for the at-risk infant. The purpose of this article is to describe the NNNS, provide video examples of the NNNS procedures and discuss the ways in which the exam has been used.
08:34
Thinking Too Much Impairs Decision-Making
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2023
Source: Peter Mende-Siedlecki & Jay Van Bavel—New York University When we are considering a tough choice between two or more attractive options, we often end up actively weighing the pros and cons of each alternative. By reflecting on their advantages and disadvantages, we attempt to fit a complex, subjective decision into an orderly set of criteria. However, research in psychology suggests that this sort of introspective approach might not always yield the most optimal outcomes.1 In other...
08:32
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
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Cited by 12 •
2017
We performed unilateral carotid artery occlusion on postnatal day 7-10 CD-1 mouse pups to create a neonatal hypoxic-ischemic (HI) model and investigated the effects of HI brain injury. We studied neurobehavioral functions in these mice compared to non-operated normal mice.
07:52
An Automated System for Sound Localization Testing in Hearing-Impaired Listeners
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2026
This protocol introduces an automated sound localization testing system with precise loudspeaker placement and integrated response analysis, validated in normal-hearing participants and participants with single-sided deafness. It provides a reproducible method to assess spatial hearing and supports functional classification using the International Classification of Functioning, Disability and Health (ICF) framework.
07:06
Studying Neurobehavioral Effects of Environmental Pollutants on Zebrafish Larvae
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Cited by 4 •
2020
A detailed experimental protocol is presented in this paper for the evaluation of neurobehavioral toxicity of environmental pollutants using a zebrafish larvae model, including the exposure process and tests for neurobehavioral indicators.
FAQs
Inflammatory cytokines can alter nervous-system function as part of the host immune response. Their effects may interact with blood-brain barrier function, microglial activity, and neurotransmission, changing how neural circuits support attention, memory, mood, fatigue, or behavior. Studying these linked processes helps determine whether symptoms reflect inflammation-related dysfunction rather than direct injury to nervous tissue.
The blood-brain barrier helps regulate the environment surrounding nervous tissue. When its function is altered during immune activation or infection, communication between systemic inflammatory processes and the nervous system may change. Researchers therefore consider barrier disruption alongside cytokine activity and microglial responses to explain cognitive, emotional, perceptual, or behavioral changes.
Researchers compare the observed neurobehavioral pattern with the infection, immune activation, and disease course. Attention, memory, fatigue, mood, perception, and behavior may change through inflammatory mechanisms even when the principal problem is not direct neurological injury. This distinction guides investigations of mechanisms, biomarkers, recovery, and possible interventions.
A thorough characterization can examine cognition, mood, perception, and behavior, with attention to specific changes in attention, memory, fatigue, anxiety, depression, or abnormal responses. Recording these domains separately helps reveal whether an infection is associated with a broad pattern or a more selective impairment, supporting clearer comparisons across disease courses.
The timing and course of symptoms matter because neurobehavioral effects can vary with the pathogen, the host response, and progression of disease. Tracking changes over the disease course helps researchers identify whether impairments emerge with immune activation, persist during recovery, or change as the underlying infection and inflammatory response evolve.
Characterizing neurobehavioral changes can support research into biomarkers, disease mechanisms, recovery, and interventions. It also provides a way to connect immune activation with functional outcomes such as altered attention, memory, mood, fatigue, or behavior. These observations help clarify how infection-related nervous-system effects differ among pathogens, hosts, and stages of disease.