Tail Skin Transplantation
Tail Skin Transplantation - Related Videos
06:48
Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
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Cited by 10 •
2014
Tail-skin transplantation is a powerful model for studying T cell-dependent rejection and tolerance induction during allogeneic immune responses in mice. The advantages of this protocol are minor invasive surgery, and ease of monitoring with no need to sacrifice the recipient mouse.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
06:42
Murine Skin Transplantation
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Cited by 36 •
2008
Allogeneic skin transplantation is a standard model to assay host T cell responses to MHC-disparate donor antigens. This video-article provides a visual tutorial of each step involved in performing a BALB/c-->C57BL/6 skin transplant.
10:17
The Tail Suspension Test
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Cited by 534 •
2012
The tail-suspension test is validated as an experimental procedure to assess antidepressant efficacy of drug treatments in mice. Mice are suspended by their tails for six minutes and escape-related behaviors are assessed. We describe procedures used in conducting the tail suspension test.
03:21
Murine Tail Lymphedema Model: An In Vivo Technique to Generate Sustained Lymphedema in Murine Tail
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2025
This video describes an in vivo technique to generate murine tail lymphedema, an abnormal fluid accumulation in the interstitial tissue space leading to swelling in the tail. The model is applied to study mechanisms and therapy for lymphedema.
FAQs
Major histocompatibility complex, or MHC, differences provide important donor antigens that recipient immune cells can recognize as foreign. This recognition can activate cellular and inflammatory pathways, shifting the outcome toward graft survival or rejection. Comparing genetically different donor and recipient combinations therefore helps researchers examine how tissue compatibility shapes immune responses in transplantation.
After engraftment, T cells contribute to the recipient’s cellular immune response against donor tissue. Their activity forms part of the broader immune and inflammatory pathways that determine whether the graft persists or is rejected. Studying these responses allows investigators to evaluate how cellular immunity participates in tissue incompatibility and transplantation tolerance.
Genetic backgrounds can influence the degree of tissue compatibility between donor and recipient and may alter the resulting immune response. Tail Skin Transplantation provides measurable rejection patterns for comparing these differences across experimental groups. Such comparisons can reveal how inherited immune characteristics affect graft outcomes and help distinguish responses associated with compatibility from those associated with interventions.
Researchers can compare graft survival or rejection patterns among different donor-recipient combinations, genetic backgrounds, treatments, and immune interventions. These outcomes provide an experimental readout of how recipient immune recognition affects donor tissue. Because the response is measurable, the model supports structured comparisons rather than relying only on general observations of immune activation.
The model allows investigators to examine whether immune interventions alter the response directed toward donor tissue. Outcomes can be evaluated in relation to graft survival or rejection, providing evidence about changes in immune suppression or transplantation tolerance. This makes the system useful for comparing strategies intended to reduce harmful immune recognition while preserving graft persistence.
Infection research can use this transplantation model to assess pathogen-related changes in graft outcomes. The central comparison is whether infection-associated influences modify the immune and inflammatory responses that affect graft survival or rejection. This connects tissue compatibility studies with questions about how infectious conditions may alter transplantation responses and immune regulation.