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The Tail Suspension Test
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Neuroscience
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JoVE Journal Neuroscience
The Tail Suspension Test

The Tail Suspension Test

DOI:
10.3791/3769-v

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10:17 min

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January 28, 2012

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, , , , ,
1Department of Psychiatry,University of Maryland School of Medicine, 2Tulane University School of Medicine, 3The Program in Neuroscience,University of Maryland , 4Department of Pharmacology and Experimental Therapeutics,University of Maryland School of Medicine

Chapters

  • 00:05Title
  • 01:20Introduction
  • 01:50Methods
  • 06:02Scoring
  • 09:50Conclusion

Summary

Automatic Translation

Automatic Translation

The tail-suspension test is validated as an experimental procedure to assess antidepressant efficacy of drug treatments in mice. Mice are suspended by their tails for six minutes and escape-related behaviors are assessed. We describe procedures used in conducting the tail suspension test.

Tags

Tail-suspension TestMouse Behavioral TestAntidepressant DrugsDepression-related BehaviorsHigh-throughput ScreeningDrug DiscoveryProspective Antidepressant CompoundsImplementation DetailsPotential ProblemsTail Climbing BehaviorC57BL/6 Mouse StrainPlastic CylinderManual Behavior Scoring

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